61995-57-1Relevant academic research and scientific papers
Mechanically activated ring-opening reactions of N-acyl-1,2,3,4-tetrahydroisoquinolines derived from the synthesis of praziquantel intermediate
Yu, Jingbo,Wang, Zhi,Zhang, Yang,Su, Weike
, p. 6116 - 6123 (2015)
Abstract An unexpected DDQ-promoted ring-opening reaction of N-chloroacetyl-tetrahydroisoquinoline under ball milling conditions was revealed during the synthesis of Praziquantel. A variety of N-acyl-tetrahydroisoquinolines were then tested to further inv
