14028-67-2

Basic information

• Product Name: 1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone
• Synonyms: 1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone;2-Acetyl-1,2,3,4-tetrahydroisoquinoline;1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
• CAS NO: 14028-67-2
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 14028-67-2.mol
• Article Data: 37

Chemical Properties

• Melting Point: 45-46 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7))
• Boiling Point: 337.4±31.0 °C(Predicted)
• Appearance: /
• Density: 1.105±0.06 g/cm3(Predicted)
• PKA: -0.53±0.20(Predicted)
• CAS DataBase Reference: 1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone(14028-67-2)
• EPA Substance Registry System: 1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone(14028-67-2)

Safety Data

• Hazardous Substances Data: 14028-67-2(Hazardous Substances Data)

Usage

Explanation

Different sources of media describe the Explanation of 14028-67-2 differently. You can refer to the following data:
1. The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. It is a derivative of a cyclic ketone, which is a type of organic compound containing a carbonyl group (C=O) within a ring structure.
3. The compound has a dihydroisoquinoline ring (a partially saturated isoquinoline ring) connected to an ethanone (acetophenone) group.
4. Due to its unique structure, 1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone can be used as a building block or intermediate in the synthesis of various pharmaceuticals and organic compounds.
5. The compound's specific pharmacological properties are not mentioned, but its structure suggests that it may have potential applications in the field of medicine or drug development.
6. The exact uses and applications of 1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone are not explicitly stated, but they are likely to depend on the compound's unique chemical and biological characteristics.

Type of compound

Cyclic ketone derivative

Structural feature

Dihydroisoquinoline group attached to an ethanone group

Applications

Synthesis of pharmaceuticals and other organic compounds

Potential pharmacological properties

Unknown, but possible due to structural features

Uses and applications

May vary depending on specific chemical and biological properties

Upstream product

• 2744-08-3 decahydroisoquinoline 
• 108-24-7 acetic anhydride 
• 119-65-3 isoquinoline 
• 79-16-3 N-methyl-acetamide 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 56971-73-4 N-methylene-2-phenethylamine 
• 64-19-7 acetic acid 
• 87803-14-3 Methyl 1,2,3,4-Tetrahydroisoquinoline-2-carboxylate 
• 75-36-5 acetyl chloride 
• 138350-92-2 tert-butyl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate 
• 142266-67-9 N-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline 
• 67-56-1 methanol 
• 64-17-5 ethanol 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 3230-65-7 3,4-dihydroisoquinoline 
• 74315-06-3 2-acetyl-1,2,3,4-tetrahydro-1-isoquinolinone 
• 1345688-34-7 1-(2-acetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one 
• 1345688-71-2 1-(2-acetyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-4-[4-(4-chlorophenyl)piperidin-1-yl]butan-1-one hydrochloride 
• 149353-95-7 2-[(tert-butoxy)carbonyl]-1 ,2,3,4-tetrahydroisoquinoline-7-carboxylic acid 
• 61995-57-1 2,3-dichloro-5,6-dicyano-4-hydroxyphenyl acetate 
• 31404-61-2 1,2,3,4-tetrahydroisoquinoline-7-sulfonamide 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 61563-39-1 2-acetyl-7-chlorosulphonyl-1,2,3,4-tetrahydroisoquinoline 
• 81885-67-8 2-acetyl-7-amino-1,2,3,4-tetrahydro-isoquinoline 
• 42923-79-5 7-nitro-1,2,3,4-tetrahydroisoquinoline 
• 13058-73-6 7-nitroisoquinoline 

Relevant articles and documents

Environmentally benign decarboxylative: N-, O-, and S-Acetylations and acylations

An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum's acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography. This journal is

Carbonylation of C?N Bonds in Tertiary Amines Catalyzed by Low-Valent Iron Catalysts

The first iron catalysts able to promote the formal insertion of CO into the C?N bond of amines are reported. Using low-valent iron complexes, including K2[Fe(CO)4], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl3 and Nd(OTf)3, have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars).

Synthesis of acetamides using CO2, methanol, H2 and amines

Herein, we report the synthesis of acetamides from CO2, methanol, H2 and corresponding amines, which is a new route used to synthesize acetamides. It was found that the Rh catalyst with LiI/LiCl as promoters could effectively catalyze this reaction. Interestingly, no ligand was required and amine substrates played a role in accelerating the reaction.