61999-49-3

Upstream product

• 127603-91-2 Methanesulfonic acid 2-(4-methoxy-phenylcarbamoyl)-1-methyl-ethyl ester 
• 104-94-9 4-methoxy-aniline 
• 103677-67-4 N-(p-Methoxyphenyl)-3-hydroxybutanamide 
• 5437-98-9 4'-methoxyacetoacetanilide 
• 145985-24-6 4-hydroxymethyl-1-(4-methoxyphenyl)-2-azetidinone 
• 845749-60-2 4-chloromethyl-1-(4-methoxyphenyl)azetidin-2-one 
• 845749-61-3 4-bromomethyl-1-(4-methoxyphenyl)azetidin-2-one 
• 145887-49-6 rac-4-iodomethyl-1-(4-methoxyphenyl)-4-oxoazetidin-2-one 
• 870654-46-9 ethyl 3-((4-methoxyphenyl)amino)butanoate 

Downstream Products

• 140648-72-2 (3R,4S)-1-(4-Methoxy-phenyl)-4-methyl-3-(2-methyl-[1,3]dioxolane-2-carbonyl)-azetidin-2-one 
• 140667-78-3 (3R,4S)-1-(4-Methoxy-phenyl)-4-methyl-3-(2-phenyl-[1,3]dioxolane-2-carbonyl)-azetidin-2-one 
• 140648-94-8 (3R,4S)-3-[(R)-Hydroxy-(2-methyl-[1,3]dioxolan-2-yl)-methyl]-1-(4-methoxy-phenyl)-4-methyl-azetidin-2-one 
• 111390-96-6 1-(4-Methoxy-phenyl)-4-methyl-3-[2-oxo-2-phenyl-eth-(E)-ylidene]-azetidin-2-one 
• 140649-07-6 (3R,4S)-3-[(R)-Hydroxy-(2-phenyl-[1,3]dioxolan-2-yl)-methyl]-1-(4-methoxy-phenyl)-4-methyl-azetidin-2-one 
• 140649-16-7 Methanesulfonic acid (S)-[(2R,3S)-1-(4-methoxy-phenyl)-2-methyl-4-oxo-azetidin-3-yl]-(2-methyl-[1,3]dioxolan-2-yl)-methyl ester 
• 140649-31-6 Methanesulfonic acid (R)-[(2S,3R)-1-(4-methoxy-phenyl)-2-methyl-4-oxo-azetidin-3-yl]-(2-phenyl-[1,3]dioxolan-2-yl)-methyl ester 
• 111390-68-2 1-(4-Methoxy-phenyl)-4-methyl-3-[2-oxo-prop-(Z)-ylidene]-azetidin-2-one 
• 111390-67-1 1-(4-Methoxy-phenyl)-4-methyl-3-[2-oxo-prop-(E)-ylidene]-azetidin-2-one 
• 140649-63-4 1-(4-Methoxy-phenyl)-4-methyl-3-[1-(2-methyl-[1,3]dioxolan-2-yl)-meth-(Z)-ylidene]-azetidin-2-one 
• 140649-40-7 1-(4-Methoxy-phenyl)-4-methyl-3-[1-(2-methyl-[1,3]dioxolan-2-yl)-meth-(E)-ylidene]-azetidin-2-one 
• 140649-55-4 1-(4-Methoxy-phenyl)-4-methyl-3-[1-(2-phenyl-[1,3]dioxolan-2-yl)-meth-(Z)-ylidene]-azetidin-2-one 
• 140649-55-4 1-(4-Methoxy-phenyl)-4-methyl-3-[1-(2-phenyl-[1,3]dioxolan-2-yl)-meth-(E)-ylidene]-azetidin-2-one 

Relevant academic research and scientific papers

Reductive dehalogenation of 4-halogenomethyl azetidin-2-one derivatives. Synthesis of (4-oxo-azetidin-2-yl)acetonitriles

The stability of the β-lactam ring under reductive conditions was examined in order to find a selective method for the synthesis of (4-oxo-azetidin-2-yl)acetonitrile derivatives. Fifteen variously substituted 4-halogenomethyl-β-lactam derivatives were syn

Formation of 2,3-Dihydro-4(1H)-quinolones and Related Compounds via Fries-type Acid-catalysed Rearrangement of 1-Arylazetidin-2-ones

A variety of 1-arylazetidin-2-ones were treated with trifluoroacetic acid under reflux, methanesulphonic acid at 100 deg C, or conc. sulphuric acid to give the corresponding 2,3-dihydro-4(1H)-quinolones via acyl migration and N-CO fission.In the case of 1-(3-substituted phenyl)azetidin-2-ones, two positional isomeric products, 5- and 7-substituted 2,3-dihydro-4(1H)-quinolones were obtained. 4-Methyl, 4-ethoxycarbonyl, and 4-piperidin-2-yl-1-arylazetidin-2-ones and their analogues were also converted into the corresponding 2-substituted 2,3-dihydro-4(1H)-quinolones under acidic conditions.The 3-substituted 1-phenylazetidin-2-ones (36) and (37) were converted into the furoquinoline systems (38) and (40), respectively, by application of this method.