870654-46-9

Upstream product

• 33240-23-2 ethyl 3-((4-methoxyphenyl)amino)but-2-enoate 
• 104-94-9 4-methoxy-aniline 
• 141-97-9 ethyl acetoacetate 
• 33240-23-2 ethyl (Z)-3-(4-methoxyanilino)-2-butenoate 

Downstream Products

• 1258723-77-1 1-(4-methoxyphenyl)-2,5-dimethyl-6-oxo-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate 
• 1258723-96-4 N-(hex-4-yn-2-yl)-N-(4-methoxyphenyl)pentanamide 
• 61999-49-3 1-(4-methoxyphenyl)-4-methyl-2-azetidinone 

Relevant academic research and scientific papers

Stereodefined homopropargyl amines by tandem nucleophilic addition/fragmentation of dihydropyridone triflates

Dihydropyridone (DHPD) triflates undergo nucleophile-triggered fragmentation to provide homopropargyl amine derivatives, the stereochemistry of which is defined by starting from readily available β-amino esters.

Chemo- and diastereoselective reduction of β-enamino esters: A convenient synthesis of both cis- and trans-γ-amino alcohols and β-amino esters

Convenient procedures for the chemo- and diastereoselective reduction of b-enamino esters 1 are described. Both cis- and trans-γ-amino alcohols 2 or b-amino esters 3 can be prepared by reduction of b-enamino esters 1, readily available starting materials, with the use of inexpensive reagents Na/i-PrOH or NaHB(OAc)3/AcOH, respectively, and the appropriate reduction conditions. The mechanisms and diastereoselectivities for the reductions are discussed. The relative configurations and conformations of the diastereoisomeric γ-amino alcohols 2 and β-amino esters 3 obtained are established by 1H and 13C NMR study and unequivocally set by their cyclic derivatives tetrahydro-1,3-oxazines 4.