62000-57-1Relevant academic research and scientific papers
Synthesis of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound method (by machine translation)
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Paragraph 0043-0044, (2017/02/24)
The present invention discloses a synthetic chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound method, its synthesis steps are as follows: to nitryl animal pen and acetaldehyde acid ester compound as the raw material, under the catalysis of chiral organic base, the reaction in an organic solvent, first preparation of chiral 3-nitro-3-phenyl-2-hydroxy carboxylic acid ester compound, then passes through the reduction acidylated preparation of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound; this invention relates to method of cheap and easily obtained raw material, preparation of chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound less steps, the final yield is high; this invention is mainly applied to medicine intermediate chiral 3-amino-3-phenyl-2-hydroxy carboxylic acid ester compound synthesis. (by machine translation)
