62012-47-9Relevant academic research and scientific papers
Method for synthesizing chiral deuterated primary alcohol
-
Paragraph 0031-0036; 0129-0133, (2021/05/29)
The invention discloses a method for synthesizing chiral deuterated primary alcohol. The method comprises the following step: reacting an aldehyde compound in an aprotic organic solvent at room temperature under the action of a chiral cobalt catalyst by t
Convenient synthesis of optically active deuterated primary alcohols via deuteride reduction of acetals derived from homochiral (1R*,2R*)-3,3,3-trifluoro-1-phenylpropane-1,2-diols
Morelli, Carlo F.,Cairoli, Paola,Marigolo, Tiziana,Speranza, Giovanna,Manitto, Paolo
experimental part, p. 351 - 354 (2009/08/08)
(1R)-1-Deuterated alcohols with high enantiomeric excess were prepared via TiCl4/Et3SiD reduction of acetals arising from the reaction of aldehydes with (1S,2S)-3,3,3-trifluoro-1-phenylpropane-1,2-diol 9. Such a chiral auxiliary was
Incorporation of deuterium-labelled analogs of isopentenyl diphosphate for the elucidation of the stereochemistry of rubber biosynthesis
Scholte, Andrew A.,Vederas, John C.
, p. 730 - 742 (2007/10/03)
A series of six deuterium-labelled analogs of isopententyl diphosphate (IPP) was prepared to investigate the detailed stereochemical course of addition of C5 units during rubber biosynthesis in Hevea brasiliensis and Parthenium argentatum. These analogs were incorporated into the cis-polyisoprene chain by rubber transferase in rubber particles, and the stereochemistry was determined by 2H-NMR analysis of the polymer or of levulinic acid derivatives obtained from its ozonolytic degradation. Results indicate that rubber chain elongation occurs with loss of the pro-S hydrogen of IPP, addition of the allylic diphosphate to the si face of IPP and inversion of stereochemistry at the carbon bearing the diphosphate. The Royal Society of Chemistry.
