620164-01-4Relevant academic research and scientific papers
Copper-ClickFerrophos-complex-catalyzed enantioselective reductive aldol reaction
Kato, Minoru,Oki, Hiroshi,Ogata, Kenichi,Fukuzawa, Shin-Ichi
experimental part, p. 1299 - 1302 (2009/12/03)
We have prepared several ClickFerrophos families and tested for the Cu(I)-catalyzed asymmetric reductive aldol reaction of ketones and aldehydes with an acrylic ester in the presence of phenylsilane. The Cu(I)-ClickFerrophos complex is efficient for the r
Copper(I)-catalyzed enantio- and diastereoselective tandem reductive aldol reaction
Chuzel, Olivier,Deschamp, Julia,Chausteur, Christophe,Riant, Olivier
, p. 5943 - 5946 (2007/10/03)
(Chemical Equation Presented) An efficient method for the enantioselective tandem reductive aldol reaction of methyl acrylate with aldehydes is reported. By using a copper-(I) precursor and a proper diphosphane ligand, high reactivities can be reached, with TOF up to 40 000 h-1. Taniaphos-based ligands lead to enantioselectivities of up to 97% in the case of the major syn diastereoisomer.
DIRECT, ENANTIOSELECTIVE ALDOL COUPLING OF ALDEHYDES USING CHIRAL ORGANIC CATALYSTS
-
Page/Page column 22-23, (2008/06/13)
Nonmetallic, chiral organic catalysts are used to catalyze an enantioselective aldol coupling reaction between aldehyde substrates. The reaction may be carried out with a single enolizable aldehyde, resulting in dimerization to give a β-hydroxy aldehyde,
Synthesis of Optically Active (E)-1-Alkoxymethoxybut-2-enyl(tributyl)stannanes: Stereochemistry of their Thermal Reactions with Aldehydes
Jephcote, Vincent J.,Pratt, Andrew J.,Thomas, Eric J.
, p. 1529 - 1535 (2007/10/02)
(1R)- and (1S)-1--(E)-but-2-enyl(tributyl)stannanes (8) and (9), whose configurations were assigned by correlation with (2R)- and (2S)-pentan-2-ol (14) and (15), react stereoselectively on heating with benzaldehyde to give (3S,4S)- and (3R,4R)-4-hydroxy-3-methyl-(Z)-1,2-enol ethers (16) and (18), respectively, the configurations of these products being established by correlation with pseudoephedrine.
