620167-50-2

Upstream product

• 100-44-7 benzyl chloride 
• 2698-69-3 4-formyl-2-methoxy-3-nitrophenyl acetate 
• 881-68-5 vanillin acetate 
• 620167-49-9 (4-benzyloxy-2-bromo-3-methoxy-phenyl)-methanol 
• 499218-04-1 4-(benzyloxy)-2-bromo-3-methoxybenzaldehyde 
• 89984-24-7 2-bromo-4-hydroxy-3-methoxy-benzaldehyde 

Downstream Products

• 620167-52-4 2-(4-benzyloxy-2-bromo-3-methoxy-benzyl)-3-methyl-4-oxo-cyclohex-2-enone 
• 620167-54-6 1-benzyloxy-3-bromo-4-(2,2-dimethyl-6-methylene-cyclohexylmethyl)-2-methoxy-benzene 
• 620167-53-5 2-(4-benzyloxy-2-bromo-3-methoxy-benzyl)-3,3-dimethyl-cyclohexanone 
• 620167-67-1 3-(4-benzyloxy-2-bromo-3-methoxy-benzyl)-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid methyl ester 
• 620167-51-3 3-(4-benzyloxy-2-bromo-3-methoxy-benzyl)-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

General route to 4a-methylhydrofluorene diterpenoids: Total syntheses of (±)-taiwaniaquinones D and H, (±)-taiwaniaquinol B, (±)-dichroanal B, and (±)-dichroanone

A general and convergent route for the synthesis of the 4a-methylhydrofluorene diterpenoids has been established through a common hexahydrofluorenone intermediate (10) obtained via Pd(0)-catalyzed reductive cyclization of a substituted 2-(2-bromobenzyl) methylene cyclohexane (13). The strategy has been successfully utilized for the synthesis of (±)-taiwaniaquinones D (3) and H (5), (±)-taiwaniaquinol B (1), (±)-dichroanal B (7), and (±)-dichroanone (8).

First Total Synthesis of the 4a-Methyltetrahydrofluorene Diterpenoids (±)-Dichroanal B and (±)-Dichroanone

(Matrix presented) A simple synthesis of the 4a-methyltetrahydrofluorene diterpenoids (±)-dichroanal B and (±)-dichroanone has been achieved through a common hexahydrofluorenone intermediate obtained via Pd(0)-catalyzed reductive cyclization of a substituted 2-(2-bromobenzyl) methylene cyclohexane.