89984-24-7Relevant articles and documents
BORON-CONTAINING SMALL MOLECULES
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, (2017/09/19)
Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.
THE 5,6-DIMETHOXY-1, 1-DIOXOBENZO(B)THIOPHENE-2-METHYLOXYCARBONYL (DM-BSMOC) AND RELATED AMINO-PROTECTING GROUPS
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, (2015/02/02)
Amino acid protecting groups are provided for use in peptide synthesis. Particular compounds disclosed include 5,6-dimethoxy-l,l-dioxobenzo[b]thiophi methyloxycarbonyl (DM-Bsmoc) and related amino-protecting groups.
1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS
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, (2014/10/03)
Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:
General route to 4a-methylhydrofluorene diterpenoids: Total syntheses of (±)-taiwaniaquinones D and H, (±)-taiwaniaquinol B, (±)-dichroanal B, and (±)-dichroanone
Banerjee, Mainak,Mukhopadhyay, Ranjan,Achari, Basudeb,Banerjee, Asish Kr.
, p. 2787 - 2796 (2007/10/03)
A general and convergent route for the synthesis of the 4a-methylhydrofluorene diterpenoids has been established through a common hexahydrofluorenone intermediate (10) obtained via Pd(0)-catalyzed reductive cyclization of a substituted 2-(2-bromobenzyl) methylene cyclohexane (13). The strategy has been successfully utilized for the synthesis of (±)-taiwaniaquinones D (3) and H (5), (±)-taiwaniaquinol B (1), (±)-dichroanal B (7), and (±)-dichroanone (8).
First Total Synthesis of the 4a-Methyltetrahydrofluorene Diterpenoids (±)-Dichroanal B and (±)-Dichroanone
Banerjee, Mainak,Mukhopadhyay, Ranjan,Achari, Basudeb,Banerjee, Asish Kr.
, p. 3931 - 3933 (2007/10/03)
(Matrix presented) A simple synthesis of the 4a-methyltetrahydrofluorene diterpenoids (±)-dichroanal B and (±)-dichroanone has been achieved through a common hexahydrofluorenone intermediate obtained via Pd(0)-catalyzed reductive cyclization of a substituted 2-(2-bromobenzyl) methylene cyclohexane.
Stereochemistry and Mechanisms of the 3-Carboxymuconate Fungal Pathway in Neurospora SY4a
Hill, Robert A.,Kirby, Gordon W.,O'Loughlin Gary J.,Robins, David J.
, p. 1967 - 1972 (2007/10/02)
The cyclisation of cis,cis-3-carboxymuconic acid 2, catalysed by cycloisomerase enzyme of Neurospora crassa SY4a, has been shown to occur by syn addition of the 1-carboxy group to the 4,5-double bond to give (S)-(-)-carboxymuconolactone 3.Thus, the absolute configuration of the lactone 3 was determined by ozonolysis to give (S)-malic(L-malic) acid.Furthermore, incubation of trisodium cis,cis-3-carboxy-5-deuteriomuconate 9 then ozonolysis of the derived lactone 28 gave (2S,3S)-3-deuteriomalic acid 29.This evidence for syn addition was confirmed by a complementary incubation of undedeuteriated 3-carboxymuconate in deuterium oxide, giving the lactone 31 and hence (2S,3R)-3-deuteriomalic acid 32. The degradation of 3-carboxymuconolactone 3 by multifunctional enzyme complex of Neurospora, to give 3-oxoadipic acid 5, has been studied with the deuteriated trisodium muconates 27, 14 and 20.The overall transformation has been found to involve an intramolecular, suprafacial 1,3-shift of hydrogen (or deuterium) from C-4 in the lactone to C-5 in the oxoadipic acid.The location and stereochemistry of deuterium in the oxoadipic acids 44 and 45 were esteblished by conversion of these acids into the optically active 2-deuteriosuccinic acids 46 and 47, respectively.The 1,3-shift provides compelling eveidence for the formation of the enol lactone 4 as an enzyme-bound intermediate.Successive enzymic hydrolysis and decarboxylation would then complete the biosynthesis of 3-oxoadipic acid 5.
O-(DIHYDROBENZOFURANYL)-DIBENZO-α-PYRONES FROM UMTIZA LISTERANA
Burger, Adrian P. N.,Brandt, Edward V.,Roux, David G.
, p. 2813 - 2818 (2007/10/02)
The novel metabolites (2'S,3'R)-3,10-dihydroxy-9-O-(6'-hydroxy-2'-hydroxymethyldihydrofuran-3-yl)-dibenz--pyran-6-one and its 5',6'-dihydroxy analogue are accompanied in the heartwood of Umtiza listerana by several known flavonoids and the parent 3,9,10-trihydroxydibenz--pyran-6-one.The latter, used for structural elucidation of the complex dibenzo-α-pyrones, was synthesized via a Hurtley condensation.Key Word Index-Umtiza listerana; Leguminosae; heartwood metabolites; (2'S,3'R)-3,10-dihydroxy-9-O-(6'-hydroxy-2'-hydroxymethyldihydrobenzofuran-3-yl)-dibenz--pyran-6-one; (2'S,3'R)-3,10-dihydroxy-9-O-(5',6'-dihydroxy-2'-hydroxymethyldihydrobenzofuran-3-yl)-dibenz--pyran-6-one; 3,9,10-trihydroxydibenz--pyran-6-one; flavonoids; 1H NMR; synthesis.
