62018-13-7Relevant academic research and scientific papers
In vitro metabolism of a new 4 hydroxycoumarin anticoagulant. Structure of an unusual metabolite
Thonnart,Vanhaelen,Vanhaelen Fastre
, p. 604 - 606 (1977)
The metabolism of clocoumarol, 3-[1-[p-(2-chlorethyl)phenyl]butyl]-4-hydroxycoumarin, by rat liver microsomes was investigated. The chemical structure of the main metabolite is 6-[1-hydroxy-2-oxo-3-[p-(2-chloroethyl)-phenyl]hexylidene]-2,4 cyclohexadien-1-one; such a structure has not been previuously reported for metabolites from anticoagulants of the 4-hydroxycoumarin group.
