In vitro metabolism of a new 4 hydroxycoumarin anticoagulant. Structure of an unusual metabolite

Article abstract of DOI:10.1021/jm00214a037

The metabolism of clocoumarol, 3-[1-[p-(2-chlorethyl)phenyl]butyl]-4-hydroxycoumarin, by rat liver microsomes was investigated. The chemical structure of the main metabolite is 6-[1-hydroxy-2-oxo-3-[p-(2-chloroethyl)-phenyl]hexylidene]-2,4 cyclohexadien-1-one; such a structure has not been previuously reported for metabolites from anticoagulants of the 4-hydroxycoumarin group.