Journal of Medicinal Chemistry p. 604 - 606 (1977)
Update date:2022-08-05
Topics:
Thonnart
Vanhaelen
Vanhaelen Fastre
The metabolism of clocoumarol, 3-[1-[p-(2-chlorethyl)phenyl]butyl]-4-hydroxycoumarin, by rat liver microsomes was investigated. The chemical structure of the main metabolite is 6-[1-hydroxy-2-oxo-3-[p-(2-chloroethyl)-phenyl]hexylidene]-2,4 cyclohexadien-1-one; such a structure has not been previuously reported for metabolites from anticoagulants of the 4-hydroxycoumarin group.
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Doi:10.1134/S1070428020060068
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(1976)Doi:10.1248/cpb.33.1793
(1985)Doi:10.1021/jo00427a024
(1977)Doi:10.1021/ol035253m
(2003)
