62020-09-1

Basic information

• Product Name: METHYL METHANESULFONYLACETATE
• Synonyms: METHYL 2-(METHYLSULFONYL)ACETATE;METHANESULFONYLACETIC ACID METHYL ESTER;METHYL METHANESULPHONYLACETATE;METHYL METHANESULFONYLACETATE;Methanesulphonylacetic acid methyl ester;METHANESULPHONYLACETIC ACID METHYL ESTER,METHYL METHANESULFONYLACETATE;Methyl methylsulfonylacetate, 98+%;Methyl methanesulfonylacetate, 98+%
• CAS NO: 62020-09-1
• Molecular Formula: C₄H₈O₄S
• Molecular Weight: 152.17
• Mol File: 62020-09-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 62 °C
• Boiling Point: 296.3 °C at 760 mmHg
• Flash Point: 133 °C
• Appearance: crystalline powder
• Density: 1.277 g/cm³
• Vapor Pressure: 0.00145mmHg at 25°C
• Refractive Index: 1.437
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in methanol. Insoluble in water.
• BRN: 2412782
• CAS DataBase Reference: METHYL METHANESULFONYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL METHANESULFONYLACETATE(62020-09-1)
• EPA Substance Registry System: METHYL METHANESULFONYLACETATE(62020-09-1)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 62020-09-1(Hazardous Substances Data)

Usage

Uses

Methyl methylsulfonylacetate is used as an active pharmaceutical ingredient.

InChI:InChI=1/C4H8O4S/c1-8-4(5)3-9(2,6)7/h3H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 2274-42-2 methanesulfonyl-acetonitrile 
• 20277-69-4 sodium methansulfinate 
• 96-34-4 methyl chloroacetate 
• 96-32-2 bromoacetic acid methyl ester 
• 5188-07-8 sodium thiomethoxide 

Downstream Products

• 65020-08-8 Methyl α-(methylsulfonyl)-α-(benzoyl)acetate 
• 67428-18-6 1-(1'-Methyl-2'-carbomethoxy-2'-methylsulfonylethyl)-cyclohexen 
• 67428-08-4 (E)-2-Methanesulfonyl-4-propyl-hept-4-enoic acid methyl ester 
• 1162-56-7 6-dehydroprogesterone 
• 123931-18-0 (3,20-Dioxo-4-pregnen-6β-yl)(methylsulfonyl)essigsaeure-methylester 
• 123857-92-1 (3,20-Dioxo-4-pregnen-6β-yl)(methylsulfonyl)essigsaeure-methylester 
• 3591-23-9 6-dehydrotestosterone 
• 123857-90-9 (17β-Hydroxy-3-oxo-4-androsten-6β-yl)(methylsulfonyl)essigsaeure-methylester 
• 123857-91-0 <(Androst-4-en-3,17-dion-6β-yl)methylsulfonyl>essigsaeure-methylester 
• 39834-01-0 (Z)-2-methanesulfonyl-4-propyl-hept-4-enoic acid methyl ester 

Relevant articles and documents

Synthesis of the 6-Methylencarboxylic Acid Derivatives of Testosterone and Progesterone

The methyl 6β-(phenylsulfonyl)acetate and methyl 6β-(methylsulfonyl)acetate derivatives 8 and 10, respectively, of testosterone and of progesterone (9 and 11, respectively) were synthesized by allylic alkylation of the corresponding ?-allylpalladium chloride complexes 3 and 4.Chromatographic separation of the reaction mixtures yields as main products 8a and 9a with S configuration at the new asymmetric center.By-products 8b and 9b have R configuration.The corresponding by-products were not found in reaction mixtures of 10 and 11.The by-products 9c and 11c with α-configuration at C-17 (isoprogesterone derivatives) were isolated from the corresponding reaction mixtures.Alkaline treatment of the main products leads to the 6-methylenecarboxylic acid derivatives as a result of elimination and saponification: 8a and 11a gave 16 and 17.Base-catalyzed elimination of 9a yields the α,β-unsaturated methyl ester 19.NMR spectroscopic investigations (NOE, NOESY) of 19 support the predicted E configuration.

11,12 Secoprostaglandins. 3. 8 Alkylthio(sulfinyl and sulfonyl) 12 hydroxyalkanoic acids and related compounds

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