62029-54-3Relevant academic research and scientific papers
Sulfur-Containing 1,3-Dialkylxanthine Derivatives as Selective Antagonists at A1-Adenosine Receptors
Jacobson, Kenneth A.,Kiriasis, Leonidas,Barone, Suzanne,Bradbury, Barton J.,Kammula, Udai,et al.
, p. 1873 - 1879 (1989)
Sulfur-containing analogues of 8-substituted xanthines were prepared in an effort to increase selectivity or potency as antagonists at adenosine receptors.Either cyclopentyl or various aryl substituents were utilized at the 8-position, because of the asso
Comparison of the Mass Spectra of 6-Thiotheophyllines and 6-Sulfinyltheophyllines
Bergmann, Felix,Rahat, Miriam,Frank, Arie,Deutsch, Joseph
, p. 565 - 568 (2007/10/02)
Under electron impact, 6-thiotheophyllines eliminate various fragments from the pyrimidine moiety.In a retro Diels-Alder reaction, they lose the fragment X=C=NCH3 from positions 1 and 2 of the pyrimidine ring.In 6-sulfinyltheophyllines, the sulfinyl group is the main target for fragmentation; it can lose either oxygen or sulfur, and the abundance of + and + is much higher than the abundance of the molecular ion.Elimination of the sufur atom of the 6-sulfinyl substituent, with retention of its oxygen, may be explained by intermediate formation of a ring.All further fragmentation of the 6-sulfinyl derivatives proceed by a primary loss of oxygen or sulfur, followed by elimination of fragments from the pyrimidine moiety, similar to the primary processes, observed in the mass spectra of the 6-thiotheophyllines.
