Sulfur-Containing 1,3-Dialkylxanthine Derivatives as Selective Antagonists at A1-Adenosine Receptors

DOI: 10.1021/jm00128a031

Source and publish data:

Journal of Medicinal Chemistry p. 1873 - 1879 (1989)

Update date:2022-08-04

Topics: Chemical Synthesis Selective Antagonists Receptor binding assay Functional assay

Authors:

Jacobson, Kenneth A.

Kiriasis, Leonidas

Barone, Suzanne

Bradbury, Barton J.

Kammula, Udai

et al. et al.

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Article abstract of DOI:10.1021/jm00128a031

Sulfur-containing analogues of 8-substituted xanthines were prepared in an effort to increase selectivity or potency as antagonists at adenosine receptors.Either cyclopentyl or various aryl substituents were utilized at the 8-position, because of the asso

Full text of DOI:10.1021/jm00128a031

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