620611-27-0

Basic information

• Product Name: 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 4-(AMINOMETHYL)-4-FLUORO-, 1,1-DIMETHYLETHYL ESTER;TERT-BUTYL 4-(AMINOMETHYL)-4-FLUOROPIPERIDINE-1-CARBOXYLATE;1-Boc-4-(aMinoMethyl)-4-fluoropiperidine;1-Boc-4-(aMinoMethyl)-4-f...;1-Boc-4-fluoro-4-(aMinoMethyl)-piperidine;4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester PUIRTY:>95%
• CAS NO: 620611-27-0
• Molecular Formula: C₁₁H₂₁FN₂O₂
• Molecular Weight: 232.297
• Mol File: 620611-27-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 302.4 °C at 760 mmHg
• Flash Point: 136.7 °C
• Appearance: /
• Density: 1.09 g/cm³
• Refractive Index: 1.483
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.13±0.29(Predicted)
• CAS DataBase Reference: 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester(620611-27-0)
• EPA Substance Registry System: 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester(620611-27-0)

Safety Data

• Hazardous Substances Data: 620611-27-0(Hazardous Substances Data)

Usage

Uses

tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate is a useful intermediate in the synthesis of 4-aminomethyl-4-fluoropiperidine derivatves used as T-type Ca2+ channel antagonist.

InChI:InChI=1/C11H21FN2O2/c1-10(2,3)16-9(15)14-6-4-11(12,8-13)5-7-14/h4-8,13H2,1-3H3

Upstream product

• 1228765-02-3 tert-butyl 4-azidomethyl-4-fluoropiperidine-1-carboxylate 
• 620611-28-1 4-[(1,3-dioxoisoindolin-2-yl)methyl]-4-fluoropiperidinecarboxylic acid tert-butyl ester 
• 918431-90-0 tert-butyl 4-fluoro-4-((tosyloxy)methyl)piperidine-1-carboxylate 
• 614730-97-1 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 147804-30-6 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester 
• 918431-93-3 4-cyano-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 918431-91-1 tert-butyl 4-fluoro-4-((3-fluoro-5-(trifluoromethyl)benzamido)methyl)piperidine-1-carboxylate 
• 918431-94-4 tert-butyl 4-((3,5-dichlorobenzamido)methyl)-4-fluoropiperidine-1-carboxylate 

Relevant articles and documents

AMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-hydroxytryptamine 4 (5-HT4) receptor.

5-AMINO-QUINOLINE-8-CARBOXAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS

The present invention relates to novel quinoline compounds of formula (I), and their pharmaceutically acceptable salts and process for their preparation. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptor agonists.

Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like prote