62088-12-4

Basic information

• Product Name: 4-(4-NITRO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER
• Synonyms: 4-(4-NITRO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER;ethyl4-(4-nitrophenyl)-3-oxobutanoate
• CAS NO: 62088-12-4
• Molecular Formula: C₁₂H₁₃NO₅
• Molecular Weight: 251.24
• Mol File: 62088-12-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 82 °C
• Boiling Point: 379.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.251±0.06 g/cm3(Predicted)
• PKA: 10.12±0.46(Predicted)
• CAS DataBase Reference: 4-(4-NITRO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-NITRO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER(62088-12-4)
• EPA Substance Registry System: 4-(4-NITRO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER(62088-12-4)

Safety Data

• Hazardous Substances Data: 62088-12-4(Hazardous Substances Data)

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 104-03-0 4-nitrobenzeneacetic acid 
• 37517-78-5 magnesium bis(3-ethoxy-3-oxopropanoate) 
• 141-97-9 ethyl acetoacetate 
• 89186-81-2 1-ethoxy-1,3-bis[(trimethylsilyl)oxy]buta-1,3-diene 
• 586-78-7 para-nitrophenyl bromide 
• 90945-64-5 4-(4-nitrophenyl)-3-oxobutyric acid 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 32864-38-3 tert-Butyl ethyl malonate 

Downstream Products

• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 90945-64-5 4-(4-nitrophenyl)-3-oxobutyric acid 
• 72676-89-2 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 108661-93-4 ethyl 3,3-difluoro-4-(4'-nitrophenyl)butanoate 
• 116904-36-0 ethyl 4-<(4-nitrophenyl)methyl>-2-phenyl-5-pyrimidinecarboxylate 
• 119512-18-4 ethyl 4-<(4-nitrophenyl)methyl>-2-phenyl-5-thiazolecarboxylate 
• 748806-77-1 7-amino-4-(4-nitrobenzyl)-1H-quinolin-2-one 
• 1027013-31-5 4-(4-Nitro-benzoyl)-2-phenyl-thiazole-5-carbonyl chloride 
• 119512-06-0 4-(4-nitrobenzoyl)-2-phenyl-5-thiazolecarboxylic acid 
• 119512-21-9 4-(4-Nitro-benzoyl)-2-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 116904-63-3 5-bromomethyl-4-<(4-nitrophenyl)methyl>-2-phenylpyrimidine 
• 116904-61-1 5-hydroxymethyl-4-<(4-nitrophenyl)methyl>-2-phenylpyrimidine 
• 1026506-23-9 4-(4-Nitro-benzyl)-2-phenyl-pyrimidine-5-carbonyl chloride 
• 116904-39-3 4-<(4-nitrophenyl)methyl>-2-phenyl-5-pyrimidinecarboxylic acid 

Relevant articles and documents

Hauser-Heck: Efficient Synthesis of γ-Aryl-β-ketoesters en Route to Substituted Naphthalenes

γ-Aryl-β-ketoesters can be prepared in one step from aryl bromides and bis(trimethylsilyl) enol ethers using catalytic amounts of Pd(dba)2/t-Bu3P and stoichiometric amounts of Bu3SnF. The wide range of γ-(hetero)aryl-β-ketoesters that can be obtained illustrate the scope and limitations of this novel Hauser-Heck combination. γ-Aryl-β-ketoesters with a 1,3-dioxane acetal in the ortho position can easily be transformed into the hydroxy naphthoate in very good yield. Aqueous formic acid at 65 °C provides optimal conditions for this deprotective aromatization.

FLUORESCENT LANTHANIDE COMPLEX

A luminescent lanthanide complex using a photo induced electron transfer as the luminescence controlling principle is presented. The complex comprises a substituted 2-quinolinol containing a sensor group and a complex group and lanthanide ion (Ln3+). This complex is allowed to be co-present in a liquid phase with a material to be measured, and the luminescence of said complex is measured.

Studies on cerebral protective agents. VI. Synthesis of novel 4-(4- nitrobenzoyl)pyrimidine and related compounds with anti-anoxic activity

Novel pyrimidine derivatives, possessing linkages between the aryl group and the pyrimidine nucleus at the C-4 position, were prepared and tested for anti-anoxic (AA) activity in mice. Among them, 5-(4-methylpiperazin-1- ylcarbonyl)-4-(4-nitrobenzoyl)-2-p