62088-12-4

Upstream product

• 32864-38-3 tert-Butyl ethyl malonate 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 141-97-9 ethyl acetoacetate 
• 1071-46-1 hydrogen ethyl malonate 
• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 104-03-0 4-nitrobenzeneacetic acid 
• 90945-64-5 4-(4-nitrophenyl)-3-oxobutyric acid 
• 37517-78-5 magnesium bis(3-ethoxy-3-oxopropanoate) 
• 89186-81-2 1-ethoxy-1,3-bis[(trimethylsilyl)oxy]buta-1,3-diene 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 5332-96-7 1-(4-nitrophenyl)propan-2-one 
• 90945-64-5 4-(4-nitrophenyl)-3-oxobutyric acid 
• 72676-89-2 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 108661-93-4 ethyl 3,3-difluoro-4-(4'-nitrophenyl)butanoate 
• 116904-36-0 ethyl 4-<(4-nitrophenyl)methyl>-2-phenyl-5-pyrimidinecarboxylate 
• 119512-18-4 ethyl 4-<(4-nitrophenyl)methyl>-2-phenyl-5-thiazolecarboxylate 
• 748806-77-1 7-amino-4-(4-nitrobenzyl)-1H-quinolin-2-one 
• 1027013-31-5 4-(4-Nitro-benzoyl)-2-phenyl-thiazole-5-carbonyl chloride 
• 119512-06-0 4-(4-nitrobenzoyl)-2-phenyl-5-thiazolecarboxylic acid 
• 119512-21-9 4-(4-Nitro-benzoyl)-2-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 116904-63-3 5-bromomethyl-4-<(4-nitrophenyl)methyl>-2-phenylpyrimidine 
• 116904-61-1 5-hydroxymethyl-4-<(4-nitrophenyl)methyl>-2-phenylpyrimidine 
• 1026506-23-9 4-(4-Nitro-benzyl)-2-phenyl-pyrimidine-5-carbonyl chloride 
• 116904-39-3 4-<(4-nitrophenyl)methyl>-2-phenyl-5-pyrimidinecarboxylic acid 

Relevant academic research and scientific papers

Hauser-Heck: Efficient Synthesis of γ-Aryl-β-ketoesters en Route to Substituted Naphthalenes

γ-Aryl-β-ketoesters can be prepared in one step from aryl bromides and bis(trimethylsilyl) enol ethers using catalytic amounts of Pd(dba)2/t-Bu3P and stoichiometric amounts of Bu3SnF. The wide range of γ-(hetero)aryl-β-ketoesters that can be obtained illustrate the scope and limitations of this novel Hauser-Heck combination. γ-Aryl-β-ketoesters with a 1,3-dioxane acetal in the ortho position can easily be transformed into the hydroxy naphthoate in very good yield. Aqueous formic acid at 65 °C provides optimal conditions for this deprotective aromatization.

FLUORESCENT LANTHANIDE COMPLEX

A luminescent lanthanide complex using a photo induced electron transfer as the luminescence controlling principle is presented. The complex comprises a substituted 2-quinolinol containing a sensor group and a complex group and lanthanide ion (Ln3+). This complex is allowed to be co-present in a liquid phase with a material to be measured, and the luminescence of said complex is measured.

Modulation of luminescence intensity of lanthanide complexes by photoinduced electron transfer and its application to a long-lived protease probe

Luminescent lanthanide complexes (Tb3+, Eu3+, etc.) have excellent properties for biological applications, including extraordinarily long lifetimes and large Stokes shifts. However, there have been few reports of lanthanide-based functional probes, because of the difficulty in designing suitable complexes with a luminescent on/off switch. Here, we have synthesized a series of complexes which consist of three moieties: a lanthanide chelate, an antenna, and a luminescence off/on switch. The antenna is an aromatic ring which absorbs light and transmits its energy to the metal, and the switch is a benzene derivative with a different HOMO level. If the HOMO level is higher than a certain threshold, the complex emits no luminescence at all, which indicates that the lanthanide luminescence can be modulated by photoinduced electron transfer (PeT) from the switch to the sensitizer. This approach to control lanthanide luminescence makes possible the rational design of functional lanthanide complexes, in which the luminescence property is altered by a biological reaction. To exemplify the utility of our approach to the design of lanthanide complexes with a switch, we have developed a novel protease probe, which undergoes a significant change in luminescence intensity upon enzymatic cleavage of the substrate peptide. This probe, combined with time-resolved measurements, was confirmed in model experiments to be useful for the screening of inhibitors, as well as for clinical diagnosis.

Benzoxazepinones and their use as squalene synthase inhibitors

There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.

Studies on cerebral protective agents. VI. Synthesis of novel 4-(4- nitrobenzoyl)pyrimidine and related compounds with anti-anoxic activity

Novel pyrimidine derivatives, possessing linkages between the aryl group and the pyrimidine nucleus at the C-4 position, were prepared and tested for anti-anoxic (AA) activity in mice. Among them, 5-(4-methylpiperazin-1- ylcarbonyl)-4-(4-nitrobenzoyl)-2-p