37517-78-5

Usage

Uses

Used in Organic Chemistry Synthesis:
Magnesium ethyl malonate is used as a reagent for the formation of carbon-carbon bonds, facilitating complex organic synthesis processes.
Used as a Source of Magnesium:
In various chemical reactions, magnesium ethyl malonate is utilized as a source of magnesium, providing a means to incorporate this essential element into different chemical formulations.
Used in Pharmaceutical Industry:
Magnesium ethyl malonate is employed in the synthesis of bioactive compounds, contributing to the development of new pharmaceuticals with potential therapeutic benefits.
Used in the Synthesis of Bioactive Compounds:
In the pharmaceutical industry, magnesium ethyl malonate is used as a precursor for the synthesis of bioactive compounds, which may have applications in the treatment or management of various health conditions.

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 105-53-3 diethyl malonate 
• 6148-64-7 ethyl potassium malonate 
• 2414-98-4 magnesium ethylate 

Downstream Products

• 129374-48-7 ethyl 5-(4,5-diphenyl-2-oxazolyl)pentan-3-onate 
• 81581-27-3 ethyl 3-(benzo[d][1,3]dioxol-5-yl)-3-oxopropanoate 
• 154382-30-6 β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester 
• 67342-99-8 ethyl 3-oxododecanoate 
• 25022-02-0 4,4-diphenyl-acetoacetic acid ethyl ester 
• 112271-08-6 (4S)-40<(tertibutyloxycarbonyl)amino>-3-oxo-5-phenylpentanoic acid ethyl ester 
• 146072-55-1 ethyl 7-cyclopropyl-3-oxo-7-phenylhept-6-enoate 
• 146072-54-0 ethyl 7-cyclopropyl-3-oxo-7-phenylhept-6-enoate 
• 167966-33-8 3-[4-(1-Benzyloxycarbonylamino-cyclopropyl)-2,5-difluoro-phenyl]-3-oxo-propionic acid ethyl ester 
• 127045-79-8 ethyl <4-(1-benzyloxycarbonylaminocyclopropyl)-2,3,5-trifluorobenzoyl>acetate 
• 127045-77-6 3-[4-(1-Benzyloxycarbonylamino-cyclopropyl)-2,3,5,6-tetrafluoro-phenyl]-3-oxo-propionic acid ethyl ester 
• 83657-82-3 4-(2-Chloro-phenyl)-3-oxo-butyric acid ethyl ester 
• 221121-45-5 ethyl 4-(2,6-dichlorophenyl)-3-oxobutanoate 
• 894802-87-0 ethyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutanoate 

Relevant academic research and scientific papers

Biosynthesis of a fluorescent protein with extreme Pseudo-stokes shift by introducing a genetically encoded non-natural amino acid outside the fluorophore

A novel kind of fluorescent protein relying on the intramolecular interplay between two different fluorophores, one of chemical origin and one of biological origin, was developed. The fluorescent non-natural amino acid l-(7-hydroxycoumarin-4-yl)ethylglyci

A genetically encoded fluorescent amino acid

The fluorescent amino acid l-(7-hydroxycoumarin-4-yl) ethylglycine 1 has been genetically encoded in E. coli in response to the amber TAG codon. Because of its high fluorescence quantum yield, relatively large Stoke's shift, and sensitivity to both pH and

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R

The interaction of IGF-II with the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF-1R) has recently been identified as potential therapeutic target for the treatment of cancer. Understanding the interactions of IGF-II with these receptors is required for the development of potential anticancer therapeutics. This work describes an efficient convergent synthesis of native IGF-II and two non-native IGF-II analogues with coumarin fluorescent probes incorporated at residues 19 and 28. These fluorescent analogues bind with nanomolar affinities to the IGF-1R and are suitable for use in fluorescence resonance energy transfer (FRET) studies. From these studies the F19Cou IGF-II and F28Cou IGF-II proteins were identified as good probes for investigating the binding interactions of IGF-II with the IGF-1R and its other high affinity binding partners.

Improving a natural enzyme activity through incorporation of unnatural amino acids

The bacterial phosphotriesterases catalyze hydrolysis of the pesticide paraoxon with very fast turnover rates and are thought to be near to their evolutionary limit for this activity. To test whether the naturally evolved turnover rate could be improved t

NOVEL COMPOUNDS AS ANTI-MYCOBACTERIALS

The present disclosure relates to antibacterial compounds. In particular, the compounds are for inhibiting the growth of bacteria, particularly Mycobacterium tuberculosis (Mtb), and/or targeting bacteria having phospho-MurNAc-pentapeptidetranslocase. The present disclosure also relates to compositions containing these compounds and methods of the use of these compounds and compositions.

Convergent Synthesis of the Renin Inhibitor Aliskiren Based on C5-C6 Disconnection and CO2H-NH2 Equivalence

A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a simultaneous stereocontrolled generation of the C4 and C5 stereogenic centers by an asymmetric hydrogenation. Operational simplicity, step economy, and a good overall yield makes this synthesis amenable to manufacture on scale.

HIGH-SENSITIVE FLUORESCENT ENERGY TRANSFER ASSAY USING FLUORESCENT AMINO ACIDS AND FLUORESENT PROTEINS

The disclosure provides method and composition utilizing fluorescent amino acids and fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function

Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds

The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

PROCESS FOR PREPARING PENTANOIC DIACID DERIVATIVES

The present invention relates to a process for preparing pentanoic diacid derivatives useful for preparing pyrimidine derivatives, in particular as intermediates useful for preparing pyrimidine derivatives of a class that is effective at inhibiting the bi

Process for preparing C7 intermediates and their use in the preparation on N-substituted pyrrole derivatives

The present invention relates to a process for preparing C7 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids. The invention further relates to intermediates in this process.