620934-08-9Relevant academic research and scientific papers
Synthesis and analgesic activity of new pyridine-based heterocyclic derivatives
Nigade, Ganesh,Chavan, Pradeep,Deodhar, Meenakshi
, p. 27 - 37 (2012)
A series of new heterocyclic derivatives having a pyridine nucleus were synthesized. 4-(5-(2-Chlorophenyl)- 4H-1,2,4-triazol-3-yl)pyridine (7c) and 4-(5-(2- Nitrophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7d) presented the best analgesic profie of this series in hot-plate, tail-flick, and formalin-induced licking tests, which was partially prevented by pretreatment with mecamylamine, a nicotinic receptor antagonist. Springer Science+Business Media, LLC 2010.
