620937-43-1Relevant articles and documents
Silver acetate-assisted formation of amides from acyl chlorides
Leggio,Belsito,Di Gioia,Leotta,Romio,Siciliano,Liguori
, p. 199 - 202 (2014)
A mild method for the aminolysis of carboxylic acid chlorides to give amides is disclosed. Reactions are carried out in the presence of silver acetate in non-aqueous environments under heterogeneous phase conditions. Amides are easily recovered in very good to excellent yields and without racemization. The approach is successful in forming peptide bonds starting from N-(4-nitrobenzenesulfonyl)-amino acid chlorides and allows the formation of dipeptides also when N-methylated amino acid derivatives are used.