620949-25-9

Upstream product

• 620949-24-8 (2R,4aR,6S,7R,8aS)-6-Hydroxymethyl-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 602301-65-5 (2R,4aR,6S,7R,8aS)-2-(4-Methoxy-phenyl)-6-vinyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 100-39-0 benzyl bromide 
• 602301-75-7 (2R,4aR,6S,7R,8aS)-7-Benzyloxy-6-benzyloxymethyl-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine 

Downstream Products

• 918897-06-0 C₂₉H₃₃IO₅ 
• 620949-09-9 (4aR,5aS,10aR,11aS)-9-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(naphthalen-2-ylmethoxy)-tetrahydro-pyran-2-ylmethyl]-2,2-di-tert-butyl-octahydro-1,3,5,8,10-pentaoxa-2-sila-cyclohepta[b]naphthalene 
• 620949-07-7 (4aR,5aS,10aR,11aS)-9-[(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-ylmethyl]-2,2-di-tert-butyl-octahydro-1,3,5,8,10-pentaoxa-2-sila-cyclohepta[b]naphthalene 
• 620949-08-8 (2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-2-((4aR,5aS,10aR,11aS)-2,2-di-tert-butyl-octahydro-1,3,5,8,10-pentaoxa-2-sila-cyclohepta[b]naphthalen-9-ylmethyl)-tetrahydro-pyran-3-ol 
• 620949-06-6 [(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-acetonitrile 
• 620949-04-4 [(2R,3S,5R,6S)-5-Benzyloxy-6-benzyloxymethyl-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-acetaldehyde 
• 918897-14-0 C₁₆H₂₁O₆Si(C₄H₉)2(CH₃)(OC₇H₇)(CH₂OC₇H₇) 
• 918897-19-5 C₁₆H₂₁O₆Si(C₄H₉)2(SC₂H₅)(OC₇H₇)(CH₂OC₇H₇) 
• 918897-13-9 C₄₁H₆₀O₈SSi 
• 918897-12-8 C₄₃H₆₆O₈S₂Si 
• 929075-06-9 C₃₉H₅₆O₉Si 
• 918897-18-4 C₄₇H₆₄O₁₀Si 
• 918897-11-7 C₄₇H₆₄O₁₀Si 
• 918897-17-3 C₄₇H₆₆O₁₀Si 

Relevant academic research and scientific papers

Convergent synthesis of trans-fused 6/n/6/6 (n=7, 8) tetracyclic ether system via α-cyano ethers

A convergent method for synthesizing 6/n/6/6 (n=7, 8) tetracyclic ether system via two-rings construction of the central n/6 ring system was developed. The key steps of the present synthesis involve a ring-closing metathesis reaction for the construction of the seven- and eight-membered rings, and reductive etherification for the tetrahydropyrans. Unification of the two fragments through acetal formation, followed by regioselective cleavage of the acetal using TMSCN/TMSOTf in the presence of 2,6-di-tert-butyl-4-methylpyridine, afforded the α-cyano ether, of which the nitrile group was manipulated to give the precursors of the ring-closing reactions.

Design and synthesis of an artificial ladder-shaped polyether that interacts with glycophorin A

Ladder-shaped polyether (LSP) compounds, such as brevetoxins and ciguatoxins, are thought to interact with transmembrane (TM) proteins. As a model LSP compound, we designed and synthesized an artificial tetracyclic ether (1) and evaluated its interaction