62095-56-1Relevant academic research and scientific papers
Direct amination of phenols under metal-free conditions
Yu, Jianzhong,Wang, Yongtao,Zhang, Peizhi,Wu, Jun
, p. 1448 - 1454 (2013/07/26)
Herein, we disclose the metal-free synthesis of arylamines via the direct amination of phenols using aminating reagents. This reaction procedure uses easy accessible aminating reagents and provides a versatile synthetic route to a broad range of arylamines with various functionalities in good to excellent yield. By using a two-step route of amination and oxidative coupling reaction, we synthesized three naturally occurring carbazole alkaloids: murrayafoline A, mukonine, and clausenine from two commercially available phenols. Georg Thieme Verlag Stuttgart · New York.
Mesoporous Structured Silica - An improved catalyst for direct amide synthesis and its application to continuous flow processing
Comerford, James W.,Farmer, Thomas J.,MacQuarrie, Duncan J.,Breeden, Simon W.,Clark, James H.
, p. 282 - 293 (2013/01/16)
We recently published details of an effective, reusable and benign heterogeneous amidation catalyst based on thermal treatment of amorphous K60 silica, however the loading of catalyst required was high for some reactions. We report herein our further development of a series of heterogeneous catalysts based on structured silica (SBA) that retain all the green credentials of the previously described amorphous silica, but with increased efficiency. These catalysts were then utilised in continuous flow systems, achieving excellent conversions with dramatically reduced reaction times. ARKAT-USA, Inc.
Clean, reusable and low cost heterogeneous catalyst for amide synthesis
Comerford, James W.,Clark, James H.,MacQuarrie, Duncan J.,Breeden, Simon W.
supporting information; experimental part, p. 2562 - 2564 (2009/10/16)
We have developed a heterogeneous silica catalyst that can effectively catalyse amide synthesis from acid and amine, without production of toxic by-products and with the advantage of being readily available, low cost, environmentally benign and reusable. The Royal Society of Chemistry 2009.
