620950-15-4Relevant academic research and scientific papers
Dl-hydroxy-alkyl-phenylamides having anticonvulsive activity
-
Page/Page column 3, (2008/06/13)
New anticonvulsant compounds were synthesized and they include the compounds: DL-2-hydroxy-2-(3′,5′-bistrifluoromethylphenyl)butyramide, DL-2-hydroxy-2-(4′-trifluoromethylphenyl)butyramide, DL-2-hydroxy-2-(3′,4′-dichlorophenyl)butyramide, DL-2-hydroxy-2-(
Synthesis and pharmacological evaluation of some DL-dichlorophenyl alcohol amides anticonvulsants
Meza-Toledo, Sergio Enrique,Olea-Gomez, Arturo,Mora-Ramirez, Erika Y.,Peralta-Cruz, Javier,Nogueron-Chirinos, Jaisel B.
, p. 830 - 834 (2007/10/03)
The anticonvulsant activity of a homologous series of DL-dichlorophenyl alcohol amides is described. The compounds DL-2-hydroxy-2-(3′,4′- dichlorophenyl) butyramide (4, CAS 620950-11-0), DL-3-hydroxy-3-(3′, 4′-dichlorophenyl) pentanamide (5, CAS 620950-15-4) and DL-4-hydroxy-4-(3′,4′-dichlorophenyl) hexanamide (6, CAS 620950-17-6) were prepared and tested. Compounds 4, 5 and 6 exhibited a significant activity in seizures induced by pentetrazol. Incorporation of chlorine in the phenyl ring increased their potency. Compound 4 exhibited a slightly lower activity than the reference drug phenobarbital (CAS 50-06-6).
