620966-85-0Relevant academic research and scientific papers
Synthesis of Pt(II) complexes of the type [Pt(1,10-phenanthroline)(SArFn)2] (SArFn = SC6H3-3,4-F2; SC6F4-4-H; SC6F5). Preliminary evaluation of their in vitro anticancer activity
Alí-Torres, Jorge,Backman-Blanco, Geraldine,Cano-Sanchez, Patricia,Flores-Gaspar, Areli,Hernandez-Ortega, Simón,Morales-Morales, David,Orjuela, Adrian L.,Ramírez-Apan, María Teresa,Reyes-Martínez, Reyna,Valdés, Hugo
, (2020)
A series of Pt(II) complexes of the type [Pt(1,10-phenanthroline)(SArFn)2] (SArFn = SC6H3-3,4-F2 (1); SC6F4-4-H (2); SC6F5 (3)) were synthesized from [Pt(1,10-phenanthroline)(Cl)2] and [Pb(SArFn)2] via metathesis reactions. The complexes were fully characterized including the unambiguous determination of their molecular structures by single-crystal X-ray diffraction techniques, showing the metal centers to be into a slightly distorted square-planar environments. The in vitro cytotoxic activity of the complexes was evaluated on six cancerous cell lines, i.e: glial cells of nervous central system (U-251), prostate (PC-3), leukemia (K-562), colon (HCT-15), breast (MCF-7) and lung (SKLU-1); we also included a healthy cell line of COS-7 (African green monkey kidney) for comparative purposes. We found that complex 2 was selective for PC-3. In addition, the IC50 values for the series of complexes were determined using the U-251, HCT-15 and SKLU-1 cancerous cell lines, as well as in the healthy cell line (COS-7), where complex 1 exhibited the best activity, with IC50 values going from 4.56 to 4.78 μM. These studies where further complemented with DNA docking theoretical calculations and DNA affinity experiments.
PtII Diimine Chromophores with Perfluorinated Thiolate Ligands: Nature and Dynamics of the Charge-Transfer-to-Diimine Lowest Excited State
Weinstein, Julia A.,Blake, Alexander J.,Davies, E. Stephen,Davis, Adrienne L.,George, Michael W.,Grills, David C.,Lileev, Igor V.,Maksimov, Alexander M.,Matousek, Pavel,Mel'Nikov, Mikhail Ya.,Parker, Anthony W.,Platonov, Vyacheslav E.,Towrie, Michael,Wilson, Claire,Zheligovskaya, Natalia N.
, p. 7077 - 7085 (2008/10/08)
The synthesis of new PtII diimine complexes bearing perfluorinated thiolate ligands, PtII(NN)(4-X-C6F 4-S)2, where NN = 2,2′-bipyridine or 1,10-phenanthroline and X = F or CN, is reported, together with an investigation of the nature and dynamics of their lowest excited states. A combined UV-vis, (spectro)electrochemical, resonance Raman, and time-resolved infrared (TRIR) study has suggested that the HOMO is mainly composed of thiolate(φ)/S(p)/Pt(d) orbitals and that the LUMO is largely localized on the φ* (diimine) orbital, thus revealing the {charge-transfer-to-diimine} nature of the lowest excited state. An enhancement of the thiolate ring vibrations, C-F vibrations, and the vibration of the CN-substituent on the thiolate moiety was observed in the resonance Raman spectra, whereas no such enhancement was seen for the nonfluorinated analogues. Thus, the introduction of fluorine substituents on the thiolate moiety probably leads to a more pronounced contribution of the intrathiolate modes to the HOMO compared to the analogous complexes with nonfluorinated thiolates. Furthermore, the introduction of the p-CN group into the thiolate moiety has allowed the dynamics of the lowest excited state of Pt(bpy)(4-CN-C6F 4-S)2 to be monitored by picosecond TRIR spectroscopy. The dynamics of the lowest {charge-transfer-to-diimine} excited state are governed by ca. 2-ps vibrational cooling and 35-ps back electron transfer.
