62107-82-8

Upstream product

• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 3116-83-4 sodium salicylate 
• 89-95-2 2-methyl-benzyl alcohol 
• 638-56-2 1,11-dichloro-3,6,9-trioxaundecane 
• 112-60-7 Tetraethylene glycol 
• 55400-73-2 ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) dimethanesulfonate 
• 90-02-8 salicylaldehyde 

Downstream Products

• 165131-50-0 1,11-bis<2-(dibutylphosphinoylmethyl)phenoxy>-3,6,9-trioxaundecane 
• 1100754-31-1 C₂₂H₂₈O₈ 
• 1629992-65-9 C₂₂H₃₀O₇ 
• 1629992-91-1 C₂₈H₃₄O₇ 
• 857336-07-3 1-{2-[2-(2-{2-[2-(2-propynoyl-phenoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-phenyl}-propynone 
• 132545-32-5 1,8-Bis<2-(4-antipyryliminomethine)phenoxy>-3,6,9-trioxaundecane 

Relevant academic research and scientific papers

DIMER COMPOUNDS, AND USE IN BINDING TOXIC REPEATS OF RNA

Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are dimeric inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.

Dynamic polymer blends - Component recombination between neat dynamic covalent polymers at room temperature

Dynamic polymers based on acylhydrazone bonds in the linear main chains were found to show bond exchange leading to crossover component recombination as neat polymers even at room temperature under acid catalysis, thus generating randomized copolymers. Th

Modular synthesis of triaroylbenzene-derived crownophanes

An isomeric series of homologous crownophanes (i.e., macrocycles possessing structural features of crown ethers and cyclophanes) has been prepared via a concise and modular synthetic route. Macrocyclization is achieved in reasonable yield during the course of an enaminone-triggered benzannulation with bis(aryl ethynyl ketone) reaction partners. The crownophanes examined were active alkali cation binding agents in the gas phase, but failed to exhibit ionophoric properties in solution. On the basis of X-ray crystallographic analysis, it is concluded that the cyclophane framework of these macrocycles is too large and rigid to allow efficient interaction with the cations examined.

Syntheses and Reactions of Crown Ether-Bridged Stilbenes

A high yield synthesis of o,o' crown ether-bridged stilbenes 3b-e by reductive McMurry condensation of (2-formylphenyl)oligoethylene glycols 2b-e with facile (E/Z) diastereomer separation by selective cation complexation is described.Derivatization of the stilbene double bonds of (E)- or (Z)-3b-e affords dihydroxy crown ethers 4c, d and 5c, d diastereo- and enantioselectively.Likewise, trans- and cis-epoxides 11b-d and 12b-d are stereospecifically obtained.A crown ether-bridged diphenylacetaldehyde 13 is formed by rearrangement of 11c or 12c.Photocyclization of 3e yields large-ring 1,8-phenanthrene crown ether 18.The crystal structures of racemic 5c and of 12d are presented.A high caesium selectivity compared to the other alkali metal and alkaline earth cations is found for ion exchange membranes with incorporated crown ether (Z)-3c. - Key Words: McMurry reaction / Crown ethers / Hydroxylation, enantioselective / Ion exchange membranes

Thermodynamics and selectivity of complexation of lithium and sodium thiocyanates with phosphorus-containing podands and compounds modeling the terminal groups of these podands

A series of model compounds and heptadentate neutral phosphorus-containing podands that differ in the conformational rigidity of the terminal groups and in the coordination properties of the phosphoryl groups were synthesized.The thermodynamic parameters