62121-85-1Relevant academic research and scientific papers
Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin
Yamane, Takehiro,Makino, Kohei,Umezawa, Naoki,Kato, Nobuki,Higuchi, Tsunehiko
supporting information; experimental part, p. 6438 - 6440 (2009/03/11)
(Chemical Equation Presented) A coordinated effort: The isomerization mechanism of prostaglandin H2 (PGH2), which is catalytically isomerized to prostacyclin or thromboxane A2 by cytochrome P450s, was investigated using a hemethiolate complex and an endoperoxide. Isomerization of endoperoxides proceeded very rapidly with this complex, whereas imidazole- or chloride-ligated heme had slight or no catalytic activity (see scheme).
