62129-02-6

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-2-BENZOOXAZOL-2-YL-PHENOL is used as a key intermediate for the synthesis of various drugs, primarily due to its ability to contribute to the development of anti-inflammatory and antibacterial agents. Its presence in the production process is essential for creating effective medications that address a range of health concerns.
Used in Chemical Industry:
In the chemical industry, 4-AMINO-2-BENZOOXAZOL-2-YL-PHENOL is utilized as a building block in the synthesis of dyes and pigments. Its chemical properties make it suitable for creating a diverse array of colorants used in various applications, from textiles to paints and coatings, enriching the spectrum of available color options.
Overall, 4-AMINO-2-BENZOOXAZOL-2-YL-PHENOL's multifaceted applications underscore its value in organic synthesis, making it an indispensable component in both medicinal and chemical production processes.

Upstream product

• 60344-96-9 2-(2′-hydroxy-5′-nitrophenyl)-1,3-benzoxazole 
• 89-57-6 5-Aminosalicylic Acid 
• 95-55-6 2-amino-phenol 

Downstream Products

• 1312023-88-3 C₁₇H₁₂N₂O₄ 
• 2533-08-6 C₁₅H₁₂N₂O₃ 
• 1422453-81-3 C₂₃H₂₈N₂O₃ 
• 1609074-41-0 2-(5'-N-octylamino-2'-hydroxyphenyl)benzoxazole 
• 1609074-40-9 2-(5-N-dodecylamino-2-hydroxyphenyl)benzoxazole 
• 1609074-38-5 2-(5-(N-3-chloro-2-hydroxypropylamino)-2-hydroxyphenyl)benzoxazole 
• 1149804-19-2 2-[5’-(N-4,6-dichloro-1,3,5-triazin-2-yl)-2’-hydroxyphenyl]benzoxazole 

Relevant academic research and scientific papers

A simple excited-state intramolecular proton transfer probe based on a new strategy of thiol-azide reaction for the selective sensing of cysteine and glutathione

A simple azido-substituted fluorescent sensor AHBO showing a selective turn-on response to cysteine (Cys) and glutathione (GSH) over homocysteine (Hcy), sulfide and other amino acids has been constructed, which is based on the mechanism of selective nucle

UV protective heterocyclic disperse azo dyes: Spectral properties, dyeing, potent antibacterial activity on dyed fabric and comparative computational study

Disperse azo dyes are synthesized and characterized by 1H NMR, 13C NMR, LC-MS, Elemental analysis, UV–visible, and fluorescence spectroscopy methods. The azo dyes show absorption maxima in the range of 460–493 nm. Dye with benzothiaz

Proton-Transfer-Based Azides with Fluorescence Off-On Response for Detection of Hydrogen Sulfide: An Experimental, Theoretical, and Bioimaging Study

This work describes the synthesis of photoactive proton transfer compounds based on the benzazolic core containing the azide group. The compounds present absorption in the UV region and fluorescence emission in the visible region of the spectra with large

Synthesis and photophysical characterization of proton transfer-based thiourea derivatives: Potential application as colorimetric naked-eye chemosensor for fluoride detection in solution

Two new thiourea derivatives were synthesized through the reaction of photoactive aminohydroxybenzazoles and p-isothiocyanate benzoic acid via nucleophilic addition reaction. The compounds were characterized using high resolution mass spectrometry with el

Synthesis, characterization and photophysics of new photoactive esipt lipophilic dyes. partition experiments with different composed liposomes

New lipophilic dyes were synthesized from a fluorescent precursor and used to produce photoactive liposomes and ethosomes made of different phospholipids. The lipophilic dyes absorbed in the ultraviolet region due to π-π* transitions and had a dual fluorescence emission in the violet-yellow regions, depending on solvent polarity. The long alkyl chain lipophilic dyes had a narrow emission band with a very regular shape, and their photophysical behaviour indicates that these dyes were inserted into the lipid bilayer. The dye with short alkyl chain appeared to be in a polar environment, which indicated this fluorophore experienced a more hydrophobic environment. Fluorescence titration experiments were also performed with this compound and the partition coefficient was determined, which showed higher values than those found in the literature for similar intramolecular proton transfer dyes, likely due to better interaction between this dye and the phospholipids, due to the alkyl chain present in the dyes.

Amphiphilic ESIPT benzoxazole derivatives as prospective fluorescent membrane probes

Fluorescent amphiphilic benzoxazole derivatives were synthesized and used to produce photoactive phosphatidylcholine (PC) liposomes by reserve-phase evaporation. The dyes absorbed in the UV region and were fluorescent in the blue-green region (determined

Synthesis and fluorescence properties of benzoxazole-1,4-dihydropyridine dyads achieved by a multicomponent reaction

Photoactive 2-(2′-hydroxyphenyl)benzoxazole-1,4-dihydropyridine (HBO-DHP) dyads were obtained by a multicomponent one-pot Hantzsch synthesis using a fluorescent aldehyde, a 1,3-dicarbonylic compound and ammonium acetate. The key step in this synthetic methodology was the synthesis of the formyl benzoxazole derivative through a Duff-modified functionalization protocol. UV-Vis absorption and fluorescence emission spectroscopies were also applied to better understand the photophysics of these compounds. The three novel fluorescent compounds were obtained in moderate yields as stable solids with absorption in the UV region and emission in the blue-green region. Preliminary results indicate that after excitation both HBO and DHP fluorophores behave independently in the HBO-DHP structure. the Partner Organisations 2014.

Synthesis and photophysical properties of novel succinimidyl benzazole derivatives, evaluated by Candida albicans ATCC 10231 fluorescent staining

New fluorescent succinimidyl benzazole derivatives were synthesised and successfully used to stain Candida albicans ATCC 10231 cells. The dyes were characterised by means of infrared, 13C and 1H NMR spectroscopies and elemental analy

BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS THEREFOR

A compound of Formula (I): wherein R1 is selected from the group consisting of an aliphatic functionality having 2 to 12 carbons, an aromatic functionality having 3 to 20 carbons, and a cycloaliphatic functionality having 3 to 20 carbons; with