62134-74-1

Upstream product

• 62134-59-2 [1-(1-Chloro-cyclohexyl)-meth-(E)-ylidene]-cyclohexyl-amine 
• 1192-88-7 1-cyclohexene-1-carboxaldehyde 
• 108-91-8 cyclohexylamine 
• 138469-42-8 Cyclohexylcarboxaldehyde cyclohexylimine 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 14441-56-6 Formyl-1-phenyl-2-trans-cyclohexan 
• 14441-56-6 (1R,2S)-2-Phenyl-cyclohexanecarbaldehyde 
• 218938-79-5 2-Phenylcyclohexanecarboxaldehyde 
• 37982-26-6 (1S,2S)-trans-2-phenylcyclohexanemethanol 
• 123166-18-7 (1R,2R)-trans-2-phenylcyclohexanemethanol 
• 1192-88-7 1-cyclohexene-1-carboxaldehyde 

Relevant academic research and scientific papers

Design, synthesis, and application of a C2 symmetric chiral ligand for enantioselective conjugate addition of organolithium to α,β-unsaturated aldimine

A C2 symmetric chiral diether ligand, (1R,2R)-1,2-dimethoxy-1,2- diphenylethane, was designed and synthesized on the basis of the concept of an asymmetric oxygen atom. Mediated by the chiral diether, high enantioselectivities were achieved in conjugate addition of organolithiums to naphthaldehyde imine and cyclic and acyclic α,β-unsaturated aldimines. The absolute configuration of the product is predictable by the model.

OXIDATION OF ALDEHYDES TO α,β-UNSATURATED ALDEHYDES VIA α-CHLOROALDIMINES

The oxidation of aldehydes to α,β-unsaturated aldehydes has been performed by a sequence of reactions involving conversion into aldimines, chlorination at the α-position to form α-chloroaldimines, base-induced dehydrochlorination and hydrolysis.The four-step transformation can be executed without isolation of the intermediates.This method has been applied to the synthesis of an artificial flavor, i.e. 2-butyl-3-phenylpropenal.