62147-00-6

Upstream product

• 616-91-1 N-acetylcystein 
• 98-88-4 benzoyl chloride 
• 495-18-1 Benzohydroxamic acid 

Relevant academic research and scientific papers

Direct Observation of Acyl Nitroso Compounds in Aqueous Solution and the Kinetics of Their Reactions with Amines, Thiols, and Hydroxamic Acids

Acyl nitroso compounds or nitrosocarhonyls (RC(O)N=O) are reactive short-lived electrophiles, and their hydrolysis and reactions with nucleophiles produce HNO. Previously, direct detection of acyl nitroso species in nonaqueous media has been provided by time-resolved infrared spectroscopy demonstrating that its half-life is about 1 ms. In the present study hydroxamic acids (RC(O)NHOH) are oxidized electrochemically in buffered aqueous solutions (pH 5.9-10.2) yielding transient species characterized by their maximal absorption at 314-330 nm. These transient species decompose via a first-order reaction yielding mainly HNO and the respective carboxylic acid and therefore are ascribed to RC(O)N=O. The sufficiently long half-life of RC(O)N=O in aqueous solution allows for the first time the study of the kinetics of its reactions with various nucleophiles demonstrating that the nucleophilic reactivity follows the order thiolate > hydroxamate > amine. Metal chelates of CH3C(O)NHOH catalyze the hydrolysis of CH3C(O)N=O at the efficacy order of CuII > ZnII > NiII > CoII where only CuII catalyzes the hydrolysis also in the absence of the hydroxamate. Finally, oxidation of hydroxamic acids generates HNO, and the rate of this process is determined by the half-life of the respective acyl nitroso compound.

SYDNONE IMINE DERIVATIVES

Compounds represented by the following general formula (1) or pharmaceutically acceptable salts thereof: [wherein Z represents -A-X-R1, a heterocycle or cycloalkyl; A represents a methylene group; X represents a sulfur atom; R1represents a benzoyl group; R2represents - N(R3)R4(wherein R3represents a methyl group; and R4represents an optionally substituted alkyl group, etc.); or a group represented by the following general formula (2): {wherein R5and R6represent each a hydrogen atom; and Y represents a group represented by the following general formula (3): (wherein R4is as defined above)}]. Because of having vasodilative effect, myocardial protective effect, antiplatelet aggregation effect, etc., the compounds represented by the above general formula (1) or pharmaceutically acceptable salts thereof are useful as drugs such as therapeutic medicines for angina pectoris.

Cobalt assisted cleavage of S-S bonds and a base-free synthesis of mercapturic acids

Base free transformation of PhSSPh to sulfides, PhSR (R = alkyl, benzyl, allyl, acyl) and N-acetyl-L-cystine to mercapturic acids [AcNHCH(COOH)CH2SR, R = alkyl, benzyl, allyl, acyl] have been achieved using Zn/cat. CoCl2/organic halide in MeCN at room temperature.