62150-45-2

Basic information

• Product Name: 4-BROMO-PYRIDINE-2-CARBONITRILE
• Synonyms: AURORA 23233;4-BROMO-PYRIDINE-2-CARBONITRILE;4-BROMO-2-CYANOPYRIDINE;OTAVA-BB BB7110952495;4-Bromopicolinonitrile;4-Bromo-2-cyanopyridine, 4-Bromopicolinonitrile;4-BroMo-2-pyridinecarbonitrile;2-Cyano-4-bromopyridine
• CAS NO: 62150-45-2
• Molecular Formula: C₆H₃BrN₂
• Molecular Weight: 183.01
• EINECS: -0
• Product Categories: pharmacetical;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;intermediate;6
• Mol File: 62150-45-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 82-84°C
• Boiling Point: 265.312 °C at 760 mmHg
• Flash Point: 114.257 °C
• Appearance: off-solid
• Density: 1.726 g/cm³
• Refractive Index: 1.544
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: -2.73±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-PYRIDINE-2-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-PYRIDINE-2-CARBONITRILE(62150-45-2)
• EPA Substance Registry System: 4-BROMO-PYRIDINE-2-CARBONITRILE(62150-45-2)

Safety Data

• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 62150-45-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-Solid

Uses

4-Bromopyridine-2-Carbonitrile is a useful synthetic intermediate.

InChI:InChI=1/C8H8BrNO2/c1-2-12-8(11)7-5-6(9)3-4-10-7/h3-5H,2H2,1H3

Upstream product

• 19524-06-2 4-bromopyridine hydrochloride 
• 1120-87-2 4-bromopyridin 
• 14248-50-1 4-bromopyridine-1-oxide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 1179360-58-7 4-bromopyridine-2-carboxamidine hydrochloride 
• 865156-53-2 7-methoxy-1,1,1-triphenyl-3-(4-bromopyridin-2-yl)-2-aza-1,λ5-phospha-heptane-1,3-diene 
• 1357587-40-6 4-[3-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyridine-2-carboxamide 
• 1357588-21-6 N-{3-[4-(2-cyanopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide 
• 1357588-20-5 4-(4-(2-cyanopyridin-4-yl)-3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 1357588-18-1 N-{3-[4-(2-cyanopyridin-4-yl)-1-(tetrahydropyran-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide 
• 1060805-69-7 1-(4-bromopyridin-2-yl)ethan-1-one 
• 1220127-06-9 1-(4-bromopyridin-2-yl)propan-1-one 
• 1187992-92-2 2-(4-Bromopyridin-2-yl)-4-hydroxypyrimidine-5-carboxylic acid 
• 1187990-82-4 2-(4-bromopyridin-2-yl)-4-hydroxy-N-(1-methyl-1-phenylethyl)pyrimidine-5-carboxamide 
• 849805-96-5 (4-phenoxypyridin-2-yl)methaneamine 

Relevant articles and documents

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure–activity relationship (SAR) studies of small molecule inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.

Substituted 4-Hydroxypyrimidine-5-Carboxamides

The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Antituberculotics. XVII. Function derivatives of 4 halogenpicolinic acid and its N oxides (Czech)

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