62156-20-1

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 90494-18-1 3-amino-2-carbamimidoyl-4-(β-D-2,3-O-isopropylidene-5-O-tritylribofuranosyl)pyrazole 
• 56703-40-3 2-(2,3-O-Isopropylidene-5-O-trityl-β-D-ribofuranosyl)acetonitrile 
• 54503-65-0 2,2-dimethyl-6-(trityloxymethyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-ol 
• 67814-68-0 2,3-O-isopropylidene-β-D-ribofuranose 
• 36468-53-8 β-D-ribofuranose 
• 59220-97-2 4-(β-2,3-O-isopropylidene-5-O-tritylribofuranosyl)-3-aminopyrazole 
• 4428-98-2 N-cyanomethanimidic acid ethyl ester 
• 77715-28-7 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile 

Relevant academic research and scientific papers

CYCLIC DINUCLEOTIDES AS STING AGONISTS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B

SYNTHESIS OF 3-AMINO-2-CARBAMIMIDOYLPYRAZOLE C-NUCLEOSIDES AND ITS CYCLIZATION TO 4-AMINOPYRAZOLO-1,3,5-TRIAZINE C-NUCLEOSIDES

4-Amino-8-(β-D-2,3-O-isopropylidene-5-O-tritylribofuranosyl)pyrazolo-1,3,5-triazine and its α-isomer were synthesized via 3-amino-2N-carbamimidoyl-4-(α and β-D-2',3'-O-isopropylidene-5'-O-tritylribofuranosyl)pyrazoles.