62182-11-0 Usage
General Description
4-Fluoro-4-deoxy-D-glucose, also known as 18F-FDG, is a positron emission tomography (PET) radiopharmaceutical used for imaging tissues in the body. It is a radioactive form of glucose that is used to detect and monitor various metabolic processes, such as tumor growth and tumor response to treatment. 18F-FDG is actively taken up by cells and is used as a marker for increased glucose metabolism, which is a common characteristic of cancerous cells. By injecting patients with 18F-FDG and using PET imaging, physicians can visualize and locate areas of increased metabolic activity, aiding in the diagnosis and monitoring of a variety of medical conditions, including cancer, heart disease, and neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 62182-11-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,1,8 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 62182-11:
(7*6)+(6*2)+(5*1)+(4*8)+(3*2)+(2*1)+(1*1)=100
100 % 10 = 0
So 62182-11-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H11FO5/c7-3-2(1-8)12-6(11)5(10)4(3)9/h2-6,8-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
62182-11-0Relevant articles and documents
Addressing the Structural Complexity of Fluorinated Glucose Analogues: Insight into Lipophilicities and Solvation Effects
St-Gelais, Jacob,C?té, émilie,Lainé, Danny,Johnson, Paul A.,Giguère, Denis
supporting information, p. 13499 - 13506 (2020/10/02)
In this work, we synthesized all mono-, di-, and trifluorinated glucopyranose analogues at positions C-2, C-3, C-4, and C-6. This systematic investigation allowed us to perform direct comparison of 19F resonances of fluorinated glucose analogues and also to determine their lipophilicities. Compounds with a fluorine atom at C-6 are usually the most hydrophilic, whereas those with vicinal polyfluorinated motifs are the most lipophilic. Finally, the solvation energies of fluorinated glucose analogues were assessed for the first time by using density functional theory. This method allowed the log P prediction of fluoroglucose analogues, which was comparable to the C log P values obtained from various web-based programs.