62189-77-9Relevant articles and documents
COMPOSITIONS AND METHODS FOR TARGETING RECEPTORS EXPRESSED IN THE GUT
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Page/Page column 39; 40, (2016/02/09)
The invention relates to novel compounds and pharmaceutical preparations thereof, as well as methods of making and using these compounds. The invention further relates to methods of treating or preventing disease using the novel compounds of the invention
A catalytic antibody programmed for torsional activation of amide bond hydrolysis
Aggarwal, Ranjana,Benedetti, Fabio,Berti, Federico,Buchini, Sabrina,Colombatti, Alfonso,Dinon, Francesca,Galasso, Vinicio,Norbedo, Stefano
, p. 3132 - 3142 (2007/10/03)
Amidase antibody 312d6, obtained against the sulfonamide hapten 4a that mimics the transition state for hydrolysis of a distorted amide, accelerates the hydrolysis of the corresponding amides 1a-3a by a factor of 103 at pH 8. The mechanisms of