6220-63-9

Usage

Uses

Used in Research Applications:
2'-Deoxycytidine-3'-monophosphate is used as a research tool for studying DNA replication, repair, and modification. It aids in understanding the mechanisms of genetic information transfer and the role of nucleotides in cellular processes.
Used in Medical Applications:
In the medical field, 2'-deoxycytidine-3'-monophosphate is utilized for its potential therapeutic applications. It can be used to develop treatments targeting DNA-related diseases and disorders, as well as for enhancing the understanding of DNA's role in various biological processes.
Used in Pharmaceutical Industry:
2'-Deoxycytidine-3'-monophosphate is used as a building block in the synthesis of nucleic acid-based drugs. It contributes to the development of new therapeutic agents that can target specific genetic abnormalities and regulate gene expression for the treatment of various diseases.
Used in Diagnostic Applications:
This nucleotide can be employed in diagnostic assays and tests to detect and monitor DNA-related abnormalities. It helps in the early identification of genetic disorders and the assessment of treatment efficacy in patients with DNA-related conditions.

Upstream product

• 13440-32-9 2'-deoxycytidine 3',5-cyclic monophosphate 
• 116113-41-8 C₆₃H₈₄N₂₁O₄₂P₇ 
• 116113-40-7 C₅₄H₇₂N₁₈O₃₆P₆ 

Downstream Products

• 951-77-9 2'-Deoxycytidine 

Relevant academic research and scientific papers

Resistance towards exonucleases of dinucleotides with stereochemically altered internucleotide phosphate bonds

Kinetic constants for the hydrolytic susceptibility of the internucleotide phosphate bond in normal dinucleotides [e.g., 2′-deoxycytidylyl- (3′>5′)-2′-deoxyuridine (dCpdU) and 2′-deoxyadenylyl- (3′→5′)-2′-deoxycytidine (dApdC)] and isomeric dinucleotides

Additional Evidence for the Exceptional Mechanism of the Acid-catalysed Hydrolysis of 4-Oxopyrimidine Nucleosides: Hydrolysis of 1-(1-Alkoxyalkyl)uracils, Seconucleosides, 3'-C-Alkyl Nucleosides and Nucleoside 3',5'-Cyclic Monophosphates

The rate constants for the acid-catalysed hydrolysis of 1-(1-alkoxyethyl)uracils and 1-alkoxymethyluracils have been determined.With both series of compounds, the hydrolysis rate is rather insensitive to the polar nature of the alkoxy group, in striking contrast with the hydrolysis of the corresponding analogues of adenine and cytosine nucleosides, which react via rate-limiting formation of an oxocarbenium ion intermediate.Furthermore, it has been shown that 3',5'-cyclic monophosphates of thymidine and uridine undergo hydrolysis of the N-glycosidic bond 760 and 260 times as fast as their parent nucleosides, while the cyclic monophosphates of 2'-deoxyadenosine and adenosine are depurinated much more slowly than the corresponding nucleosides.On this basis it is suggested that 4-oxopyrimidine nucleosides are hydrolysed by opening of the sugar ring.To obtain further evidence for this exceptional mechanism, comparative kinetic measurements with some seco- and 3'-C-alkyl nucleosides of uracil and adenine have been carried out.

SOLID PHASE SYNTHESIS OF CYCLIC OLIGODEOXYRIBONUCLEOTIDES.

The polymer supported synthesis of cyclic oligomers of deoxycytidilic acid is described, by a method based on an oligonucleotide-solid phase linkage through the amino group of the base.