62208-63-3

Basic information

• Product Name: 1-Methyl-4-(2-nitrophenyl)piperazine, 97%
• Synonyms: Piperazine, 1-methyl-4-(2-nitrophenyl)-;1-Methyl-4-(2-nitrophenyl)piperazine,97%
• CAS NO: 62208-63-3
• Molecular Formula: C₁₁H₁₅N₃O₂
• Molecular Weight: 221.2557
• Mol File: 62208-63-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 345.1±37.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.198±0.06 g/cm3(Predicted)
• PKA: 7.50±0.42(Predicted)
• CAS DataBase Reference: 1-Methyl-4-(2-nitrophenyl)piperazine, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-(2-nitrophenyl)piperazine, 97%(62208-63-3)
• EPA Substance Registry System: 1-Methyl-4-(2-nitrophenyl)piperazine, 97%(62208-63-3)

Safety Data

• Hazardous Substances Data: 62208-63-3(Hazardous Substances Data)

Usage

Purity

97%

Composition

Piperazine ring with a methyl group and a nitrophenyl group attached

Usage

Pharmaceutical and agrochemical industries as a building block for the synthesis of bioactive compounds

Importance

Unique structure and high purity make it a valuable reagent for research and development

Safety

Handle with care and in accordance with safety guidelines due to potential hazards

Upstream product

• 109-01-3 1-methyl-piperazine 
• 577-19-5 2-nitrophenyl bromide 
• 609-73-4 o-nitroiodobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 180605-36-1 2-(4-methylpiperazin-1-yl)phenylamine 
• 1430402-93-9 C₁₆H₂₁N₇OS 
• 1430402-92-8 C₁₇H₂₄N₄O₃ 

Relevant articles and documents

NOTCH INHIBITORS AND USES THEREOF

Disclosed herein, inter alia, are compounds for inhibiting Notch and uses thereof.

Design, synthesis and biological evaluation of piperazino-enaminones as novel suppressants of pro-Inflammatory cytokines

Infection triggers the release of pro-inflammatory cytokines (TNF-alpha and IL-6). Over-production, however, cause tissue injury seen in severe asthma. The ability of enaminone E121 to reduce pro-inflammatory cytokines in our laboratory encouraged further examination of its structural scaffold. Piperazino-enaminones were designed by incorporating n-arylpiperazine motif into the aromatic enaminone. Four possible modifications were explored systematically. Synthesis was accomplished by amination of the corresponding methyl/ethyl 2,4-dioxo-6-(substituted)cyclohexane-carboxylate. Sixteen novel compounds were synthesized. Biological activity was tested in J774 macrophages stimulated with lipopolysaccharides. The release of cytokines was measured via ELISA. Four compounds significantly suppressed TNF-alpha and IL-6 release in dose-dependent manner.

Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling

Iridium-catalyzed acceptorless dehydrogenative coupling of tertiary amines and arylamines has been developed. A number of benzimidazoles were prepared in good yields. An iridium-mediated C-H activation mechanism is suggested. This finding represents a novel strategy for the synthesis of benzimidazoles.