62224-24-2Relevant academic research and scientific papers
THIOPHENE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL APPLICATION OF SAME
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Paragraph 0103; 0104; 0105, (2019/04/25)
The present invention discloses a thiophene used as a uric acid transporter (URAT1) inhibitor and applicantion of the thiophene in preparing a pharmaceutical product for treating a disease related to abnormal uric acid levels, specifically in preparing a pharmaceutical product for treating hyperuricemia and gouty arthritis. The invention specifically relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.
Thieno[3,2-c]pyrazoles: A novel class of Aurora inhibitors with favorable antitumor activity
Bindi, Simona,Fancelli, Daniele,Alli, Cristina,Berta, Daniela,Bertrand, Jay A.,Cameron, Alexander D.,Cappella, Paolo,Carpinelli, Patrizia,Cervi, Giovanni,Croci, Valter,D'Anello, Matteo,Forte, Barbara,Laura Giorgini,Marsiglio, Aurelio,Moll, Juergen,Pesenti, Enrico,Pittalà, Valeria,Pulici, Maurizio,Riccardi-Sirtori, Federico,Roletto, Fulvia,Soncini, Chiara,Storici, Paola,Varasi, Mario,Volpi, Daniele,Zugnoni, Paola,Vianello, Paola
experimental part, p. 7113 - 7120 (2010/10/21)
A novel series of 3-amino-1H-thieno[3,2-c]pyrazole derivatives demonstrating high potency in inhibiting Aurora kinases was developed. Here we describe the synthesis and a preliminary structure-activity relationship, which led to the discovery of a represe
Heterobicyclic pyrazole derivatives as kinase inhibitors
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Page/Page column 23, (2008/06/13)
Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in
Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/ dibromothiazoles and arylboronic acids. Synthesis of PPARβ/δ agonists
Pereira, Raquel,Furst, Audrey,Iglesias, Beatriz,Germain, Pierre,Gronemeyer, Hinrich,De Lera, Angel R.
, p. 4514 - 4525 (2008/09/19)
A reactivity study, aided by NMR spectroscopy, allowed a mechanistic rationale to be postulated for the palladium-catalyzed regioselective coupling of arylboronic acid (and arylstannane where feasible) at the position next to the sulfur atom in functional
HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
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Page 58, (2010/02/06)
Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in
