62246-18-8

Upstream product

• 173459-80-8 benzyl [2?(1H?benzo[d][1,2,3]triazol?1?yl)?2?oxoethyl]carbamate 
• 5473-12-1 N-methylglycine methylester 

Downstream Products

• 175444-32-3 {[2-((R)-2-Benzyloxycarbonylamino-4-phenyl-butyrylamino)-acetyl]-methyl-amino}-acetic acid methyl ester 
• 175444-30-1 {[2-((R)-2-Benzyloxycarbonylamino-4-phenyl-butyrylamino)-acetyl]-methyl-amino}-acetic acid 

Relevant academic research and scientific papers

Efficient peptide coupling involving sterically hindered amino acids

(Chemical Equation Presented) Hindered amino acids have been introduced into peptide chains by coupling N-(Cbz- and Fmoc-α-aminoacyl) benzotriazoles with amino acids, wherein at least one of the components was sterically hindered, to provide compounds 3a-e, (3c +3 c′), 5a-d, (5a + 5a′), 6a-c, (6b + 6b′), 8a-c, 9a-e, 10a-d, and (10a + 10a′) in isolated yields of 41-95% with complete retention of chirality as evidenced by NMR and HPLC analysis. The benzotriazole activation methodology is a new route for the synthesis of sterically hindered peptides. (Note: compound numbers written within brackets represent diastereomeric mixtures or racemates; compound numbers without brackets represent enantiomers.)