173459-80-8

Basic information

• Product Name: Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate
• Synonyms: Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate;N-Z-(1-Benzotriazolylcarbonyl)methylamine
• CAS NO: 173459-80-8
• Molecular Formula: C₁₆H₁₄N₄O₃
• Molecular Weight: 310.30736
• Mol File: 173459-80-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 110-117°C
• Appearance: /
• Storage Temp.: ?20°C
• CAS DataBase Reference: Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate(173459-80-8)
• EPA Substance Registry System: Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate(173459-80-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 173459-80-8(Hazardous Substances Data)

Usage

Uses

Benzotriazole amino acids, or aminoacylbenzotriazolides, are versatile reagents for synthesizing peptides as well as their mimetics and conjugates. Benzotriazole amino acids have been used for the preparation of diverse derivatives including:Polypeptidal benzotriazolidesPeptidomimetics, such as aminoxypeptides, depsipeptides and heterocyclic peptidomimeticsTagged peptides and peptidomimetics, particularly those with fluorescent labelsN, O, S, and C linked peptide conjugates

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 

Downstream Products

• 152528-95-5 2-oxo-2-p-tolyl-ethyl-carbamic acid benzyl ester 
• 1381763-25-2 (S)-benzyl(2-((1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxopropan-2-yl)amino)-2-oxoethyl)carmabamate 
• 3079-63-8 (S)-2-(2-Benzyloxycarbonylamino-acetylamino)-propionic acid 
• 133639-64-2 benzyl (2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)carbamate 
• 77471-39-7 benzyl (2-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-2-oxoethyl)-carbamate 
• 58178-08-8 N-(2-hydroxyphenyl)-2-[(phenylmethoxy)carbonylamino]ethanamide 
• 7625-41-4 benzyl (2-oxo-2-(p-tolylamino)ethyl)carbamate 
• 6833-09-6 benzyl (2-oxo-2-(phenylamino)ethyl)carbamate 
• 311779-20-1 benzyl [2?[(2?aminophenyl)amino]?2?oxoethyl]carbamate 

Relevant articles and documents

Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: Antiproliferative activity, molecular docking, and SAR studies

The development of anticancer compounds targeting the colchicine-binding site of tubulin, termed colchicine-binding site inhibitors (CBSIs) is a promising research area for pharmaceutical companies and research institutes. A series of 3,5-disubstituted 1,

Chemical modification of oximes with N-protected amino acids

The modification of oximes, including 5α-steroids, with N-protected amino acids, in solution phase, using benzotriazole methodology is reported.

Gabapentin hybrid peptides and bioconjugates

Synthetic approaches to gabapentin bioconjugates that overcome the tendency of gabapentin to cyclize into its γ-lactam are studied. Gabapentin was converted by N-acylation at its N-terminus into di-, tri-, and tetrapeptides (L-Ala-Gbp, L-Val-Gbp, L-Ala-L-Phe-Gbp, Gly-L-Ala-β-Ala-Gbp). Carboxyl-activated Boc-protected gabapentin was used to N-, O-, and S-acylate small peptides and hormones to give conjugates that could also provide prodrugs containing conformationally constrained gabapentin units.