62247-00-1

Usage

Uses

Used in Textile Industry:
AKOS 90145 is used as a fluorescent brightener for enhancing the whiteness and brightness of textiles. It has the ability to absorb ultraviolet light and emit blue light, which improves the overall appearance of the fabric.
Used in Ink Industry:
AKOS 90145 is used in the ink industry to provide bright and vivid colors in various printing applications. Its fluorescent properties contribute to the enhanced visual appeal of the printed materials.
Used in Coating Industry:
In the coating industry, AKOS 90145 is used to improve the aesthetic properties of coated surfaces. Its ability to absorb ultraviolet light and emit blue light adds a unique glow and brightness to the coatings.
Used in Plastics Industry:
AKOS 90145 is also used in the plastics industry to enhance the appearance of plastic products. Its fluorescent properties can improve the color and brightness of plastic materials, making them more visually appealing.
It is important to handle AKOS 90145 with care, as it is known to be harmful if ingested or inhaled, and can cause irritation to the skin and eyes.

Upstream product

• 62247-14-7 (3-chlorophenyl)(pyridin-3-yl)methanol 
• 587-04-2 m-Chlorobenzaldehyde 
• 626-55-1 3-Bromopyridine 
• 201230-82-2 carbon monoxide 
• 63503-60-6 3-chlorophenylboronic acid 

Downstream Products

• 1585244-34-3 (3E)-4-(3-chlorophenyl)-N,N-dimethyl-4-(3-pyridyl)but-3-en-1-ammonium trifluoroacetate 
• 1585244-36-5 (3Z)-4-(3-chlorophenyl)-N,N-dimethyl-4-(3-pyridyl)but-3-en-1-ammonium trifluoroacetate 
• 1600563-76-5 (3-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(pyridin-3-yl)methanol 
• 1599524-99-8 (4-Chloro-2-(diethylamino)-3-phenoxyquinolin-6-yl)(3-chlorophenyl)(pyridin-3-yl)methanol 
• 1599525-56-0 (3-chlorophenyl)(2,4-dichloro-3-(methyl(phenyl)amino)quinolin-6-yl)(pyridin-3-yl)methanol 
• 124009-69-4 α-(3-Chlor-phenyl)-α-trichlormethyl-3-pyridinmethanol 
• 1600566-31-1 (3-chlorophenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol trifluoroacetate 
• 1599529-99-3 (4-chloro-3-(4-fluorobenzyl)-2-methoxyquinolin-6-yl)(3-chlorophenyl)(pyridin-3-yl)methanol 

Relevant academic research and scientific papers

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT

The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity. Mutations in the parasite's CQ resistance transporter (PfCRT) confer resistance to CQ by enabling the protein to transport the drug away from its site of action, and it is thought that resistance-reversers such as CP exert their effect by blocking this CQ transport activity. Here, a series of new structural analogues and homologues of CP have been synthesized. We show that these compounds (along with other in vitro CQ resistance-reversers) inhibit the transport of CQ via a resistance-conferring form of PfCRT expressed in Xenopus laevis oocytes. Furthermore, the level of PfCRT-inhibition was found to correlate well with both the restoration of CQ accumulation and the level of CQ resensitization in CQR parasites.

Palladium-N-heterocyclic carbene an efficient catalytic system for the carbonylative cross-coupling of pyridine halides with boronic acids

Carbonylative cross-coupling of different pyridyl halides with various boronic acids was studied using catalytic systems constituted of N-heterocyclic carbene type ligands and palladium. These systems easily obtained in situ from the corresponding imidazolium salt and palladium acetate appear more efficient toward bromopyridines than catalysts based on hindered and basic alkylphosphines such as tricyclohexylphosphine. Their higher efficiency was also evidenced by coupling using chloro- or dichloropyridines and chloroquinolines, which practically do not react with catalytic systems based on phosphines.