62247-14-7

Upstream product

• 626-55-1 3-Bromopyridine 
• 587-04-2 m-Chlorobenzaldehyde 
• 500-22-1 3-pyridinecarboxaldehyde 
• 108-37-2 1-bromo-3-chlorobenzene 

Downstream Products

• 1585244-34-3 (3E)-4-(3-chlorophenyl)-N,N-dimethyl-4-(3-pyridyl)but-3-en-1-ammonium trifluoroacetate 
• 62247-00-1 (3-chlorophenyl)(pyridin-3-yl)methanone 

Relevant academic research and scientific papers

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.

Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT

The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity. Mutations in the parasite's CQ resistance transporter (PfCRT) confer resistance to CQ by enabling the protein to transport the drug away from its site of action, and it is thought that resistance-reversers such as CP exert their effect by blocking this CQ transport activity. Here, a series of new structural analogues and homologues of CP have been synthesized. We show that these compounds (along with other in vitro CQ resistance-reversers) inhibit the transport of CQ via a resistance-conferring form of PfCRT expressed in Xenopus laevis oocytes. Furthermore, the level of PfCRT-inhibition was found to correlate well with both the restoration of CQ accumulation and the level of CQ resensitization in CQR parasites.

Method of regulating the growth of aquatic weeds with pyridine derivatives

A method of regulating the growth of submerged and floating aquatic weeds which comprises adding a 3-substituted pyridinemethane, pyridinemethanol, or derivative thereof, to a body of water containing the submerged and floating aquatic weeds to be regulated, in quantities sufficient to regulate the growth of the said submerged and floating aquatic weeds. The disclosure also relates to novel compositions for carrying out the method.