62247-37-4Relevant academic research and scientific papers
Selective catalytic oxidative carbonylation of amino alcohols to ureas
Diaz, Delmy J.,Hylton, Keisha-Gay,McElwee-White, Lisa
, p. 734 - 738 (2007/10/03)
Amino alcohols undergo W(CO)6-catalyzed oxidative carbonylation to the corresponding hydroxyalkylureas without protection of the hydroxyl group. Selected examples of 1,2-, 1,3-, 1,4-, and 1,5-amino alcohols were converted to the ureas in good to excellent yields, with only small amounts of the cyclic carbamates being formed. In contrast, the phosgene derivatives CDI and DMDTC undergo stoichiometric reactions with the amino alcohol substrates to afford ureas and cyclic carbamates with variable selectivity.
Precursors for the production of chiral 1,3-aminoalcohols
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, (2008/06/13)
The disclosure describes novel precursors for the preparation of chiral 1,3-aminoalcohols. The precursors are chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides produced from chiral gamma-lactones, which in turn are derived from 1,4-diols by stereoselective oxidation. The chiral 4-hydroxycarboxamides, 4-hydroxyhydroxamic acids, or 4-hydroxyhydrazides are converted into chiral 1,3-aminoalcohols by stereospecific rearrangement.
Angiotensin-converting enzyme inhibitors: Synthesis and biological activity of acyl tripeptide analogues of enalapril
Greenlee,Allibone,Perlow,Patchett,Ulm,Vassil
, p. 434 - 442 (2007/10/02)
The synthesis and biological activity of a series of inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) are described. Incorporation of the substituted N-carboxymethyl dipeptide design of enalapril (MK-421) into acyl tripeptides and larger peptides
