94670-46-9Relevant academic research and scientific papers
Preparation of modified peptides: Direct conversion of α-amino acids into β-amino aldehydes
Saavedra, Carlos J.,Boto, Alicia,Hernandez, Rosendo
experimental part, p. 4448 - 4461 (2012/07/14)
A direct method for the transformation of α-amino acids into β-amino aldehydes was developed, and applied to the modification of the C-terminal residue of peptides. The method takes place in good yields and under mild conditions. The application of this methodology to the preparation of small peptides with γ-amino alcohol units, which are precursors of analogues of peptaibol antibiotics, is also described.
One-pot conversion of α-amino acids into β-amino aldehydes or 2-acetoxyazetidines: Application to the synthesis of modified peptides
Boto, Alicia,Hernández, Rosendo,Saavedra, Carlos J.
experimental part, p. 659 - 663 (2010/09/18)
A direct method for the transformation of α-amino acids into β-amino aldehydes or 2-acetoxyazetidines is described. This work was applied to the modification of peptides. Georg Thieme Verlag Stuttgart.
β-Amidoaldehydes via oxazoline hydroformylation
Laitar, David S.,Kramer, John W.,Whiting, Bryan T.,Lobkovsky, Emil B.,Coates, Geoffrey W.
supporting information; experimental part, p. 5704 - 5706 (2010/01/31)
4-Substituted oxazolines, which are readily synthesized from naturally occurring α-amino acids, are converted efficiently and stereospecifically to β-amidoaldehydes in the presence of synthesis gas and catalytic dicobalt octacarbonyl.
Novel use of N-benzoyl-N, O-acetals as N-acylimine equivalents in asymmetric heterocycloaddition: An extended enantioselective pathway to β-benzamido aldehydes
Gizecki, Patricia,Dhal, Robert,Poulard, Celine,Gosselin, Pascal,Dujardin, Gilles
, p. 4338 - 4344 (2007/10/03)
For the first time, easily available N-(α-methoxyalkyl)amides were successfully used as synthetic equivalents of N-acylimines in an asymmetric heterocycloaddition process. The facial-controlled formation of 6-alkoxydihydrooxazines was thus achieved by SnC
Angiotensin-converting enzyme inhibitors: Synthesis and biological activity of acyl tripeptide analogues of enalapril
Greenlee,Allibone,Perlow,Patchett,Ulm,Vassil
, p. 434 - 442 (2007/10/02)
The synthesis and biological activity of a series of inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) are described. Incorporation of the substituted N-carboxymethyl dipeptide design of enalapril (MK-421) into acyl tripeptides and larger peptides
