62249-41-6

Basic information

• Product Name: (2R)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanedioic acid
• CAS NO: 62249-41-6
• Molecular Formula: C₁₂H₉NO₆
• Molecular Weight: 263.203
• Mol File: 62249-41-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 460.1°C at 760 mmHg
• Flash Point: 232.1°C
• Density: 1.64g/cm³
• Vapor Pressure: 2.92E-09mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: (2R)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanedioic acid(62249-41-6)
• EPA Substance Registry System: (2R)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanedioic acid(62249-41-6)

Safety Data

• Hazardous Substances Data: 62249-41-6(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 6893-26-1 D-Glutamic acid 

Relevant articles and documents

Amino-protected (R) - 3-amino-piperidine preparation method

The invention discloses a preparation method of amino protection (R)-3-amino piperidine, and the preparation method comprises the following steps: (1) in the presence of a first solvent or absence of a solvent, reacting a compound of formula V with benzylamine to obtain a compound of formula VI; (2) in the presence of a second solvent, performing catalytic hydrogenation of the compound of formula VI to remove benzyl to obtain the amino protection (R)-3-amino piperidine. According to the method, the defects of use of expensive metal catalysts and use of high-pressure hydrogenation and various splitting for synthesis of a chiral amino piperidine ring can be avoided, at the same time, the synthetic route is short, the process is simple, the yield is high, and the method is suitable for industrial mass production.