6226-39-7

Upstream product

• 81980-22-5 bicyclo[4.1.0]heptane-7-carbaldehyde 
• 52917-64-3 ethyl 7-norcaranecarboxylate 
• 110-83-8 cyclohexene 

Downstream Products

• 81980-22-5 bicyclo[4.1.0]heptane-7-carbaldehyde 
• 29108-24-5 2-vinylcyclohexan-1-ol 

Relevant academic research and scientific papers

Regioselective Br?nsted Acid-Catalyzed Annulation of Cyclopropane Aldehydes with N′-Aryl Anthranil Hydrazides: Domino Construction of Tetrahydropyrrolo[1,2- a]quinazolin-5(1 H)ones

A highly regioselective synthesis of tetrahydropyrrolo[1,2-a]quinazolin-5(1H)one derivatives was achieved by reacting cyclopropane aldehydes with N′-aryl anthranil hydrazides in the presence of p-toluene sulfonic acid (PTSA). The transformation involves domino imine formation and intramolecular cyclization to form 2-arylcyclopropyl-2,3-dihydroquinolin-4(1H)-one, followed by nucleophilic ring opening of the cyclopropyl ring to form desired tetrahydropyrrolo[1,2-a]quinazolin-5(1H)one in good to excellent yield with complete regioselectivity. This protocol tolerates a great variety of functional groups and thus provides a simple and step-efficient method for pyrroloquinazolinone synthesis.

Metal-Free Ring Opening Cyclization of Cyclopropane Carbaldehydes and N-Benzyl Anilines: An Eco-Friendly Access to Functionalized Benzo[b]azepine Derivatives

Herein, we report a p-toluenesulfonic acid (PTSA) initiated mild and user-friendly ring opening/domino ring opening cyclization reaction (depends on substituent present in N-benzyl aniline) of cyclopropane carbaldehyde and N-benzyl aniline towards the formation of substituted 4-amino butanal/2,3-dihydro-1H-benzo[b]azepine. The product dihydro-1H-benzo[b]azepine was also converted into the corresponding tetrahydro-1H-benzo[b]azepine. (Figure presented.).

Substituted acrylamido-penicillanic acid derivatives

Compounds of formula (I) and their derivatives: wherein X is hydrogen or a group NHR1, wherein R1 is hydrogen or an amino protecting group, and R is an optionally substituted spiro, fused or bridged bicyclic group optionally containing one or more heteroatoms selected from oxygen, nitrogen and sulphur, are new and useful in the treatment of bacterial infections in humans and animals.

Hydrogenolysis of Small Cycloalkanes, X. - Catalytic Hydrogenation of Bicycloalkanes

Dependent on n different products are obtained from bicycloalkanes by hydrogenation on Pt and Pd/C catalysts: from n = 5 onward only methylcycloalkanes of the same ring size; with n = 4 additionally 2-7 percent of cycloheptane is formed; with n = 3 ring enlargement increases to 5-20 percent and with n = 2 cyclopentane is the only product.Mainly butane is formed from bicyclobutane and no intermediate could be detected.Explanations are attempted.The expected products are produced on hydrogenation of methyl-substituted derivatives and spiroalkanes.

Cyclopropylmethyl Compounds as Probes of the Mechanism of Hydrogen Transfer by NAD(H) and Alcohol Dehydrogenase

α-Hydroxyalkylcyclopropanes are oxidised by nicotinamid-dependent horse liver alcohol dehydrogenase without cleavage of the 3-membered ring, implying that radical intermediates are improbable in these reactions.