622830-69-7

Basic information

• Product Name: C₆₉H₈₄N₆O₂₁
• Synonyms: C₆₉H₈₄N₆O₂₁
• CAS NO: 622830-69-7
• Molecular Weight: 1333.45
• Mol File: 622830-69-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₉H₈₄N₆O₂₁(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₉H₈₄N₆O₂₁(622830-69-7)
• EPA Substance Registry System: C₆₉H₈₄N₆O₂₁(622830-69-7)

Safety Data

• Hazardous Substances Data: 622830-69-7(Hazardous Substances Data)

Upstream product

• 622830-67-5 N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[O-(2-deoxy-2-acetamido-β-D-glucopyranosyl)-(1->4)-[O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->6)]-3-O-benzyl-2-deoxy-2-acetamido-β-D-glucopyranosyl]-L-asparagine tert-butyl ester 
• 622830-65-3 O-(2,3,4-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->4)-[O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->6)]-3-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide 
• 622830-63-1 O-(2,3,4-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->4)-6-O-(tert-butyldiphenylsilyl)-3-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide 
• 622830-66-4 O-(2-deoxy-2-acetamido-β-D-glucopyranosyl)-(1->4)-[O-(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-(1->6)]-3-O-benzyl-2-deoxy-2-acetamido-β-D-glucopyranosyl azide 
• 622830-64-2 O-(2,3,4-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->4)-3-O-benzyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl azide 
• 383912-99-0 FmocAsp(OBt)OBu^t 
• 129460-09-9 Fmoc-Asp-O-t-Bu 
• 70831-94-6 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-D-glucopyranosyl bromide 
• 10022-13-6 1,3,4,6-tetra-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranose 
• 132388-65-9 Fmoc-Gln(Trt)-OPfp 
• 622830-68-6 N^γ-[O-(2-deoxy-2-acetamido-β-D-glucopyranosyl)-(1->4)-[O-(α-L-fucopyranosyl)-(1->6)]-2-deoxy-2-acetamido-β-D-glucopyranosyl]-L-asparagine tert-butyl ester 

Downstream Products

• 1054749-26-6 C₄₁H₅₆F₅N₇O₂₁ 
• 622830-76-6 C₅₈H₇₉N₇O₂₁ 
• 622830-71-1 C₇₁H₈₇N₇O₂₂ 
• 622830-70-0 C₅₄H₇₄N₆O₁₉ 

Relevant articles and documents

Chemical Synthesis of CD52 Glycopeptides Containing the Acid-Labile Fucosyl Linkage

Glycopeptide 1 with the fucosylated trisaccharide, β-D-GlcNAc(1→ 4)[α-L-Fuc(1→6)]-β-D-GlcNAc, linked to the Asn of CD52 peptide was prepared by two methods, both of which used the free glycosyl Asn 12 and glycotripeptide 21 as key intermediates. Thus, after the trisaccharide was prepared and linked to Asn, the carbohydrate moiety was deprotected to give 12. From 12, 21 was constructed in homogeneous NMP solutions by elongating the peptide chain alone the N-terminus. Though the glycopeptides were easily soluble in NMP, they were barely soluble in diethyl ether, because of the free trisaccharide. Consequently, addition of diethyl ether to the reaction mixtures could precipitate the glycopeptides, and the products were conveniently isolated and purified in the solid form. The coupling of 21 with a free nonapeptide 24 in NMP afforded 1. 1 was also prepared by solid-phase synthesis, using the acid-sensitive 2-chlorotrityl resin. In this case, 21 was attached to the nonapeptide on the resin, and the resulting glycopeptide was then released with dilute acetic acid. Deprotection of the peptide under moderate acidic conditions gave 1. The acid-labile α-fucose was not affected in these syntheses.