62284-31-5Relevant academic research and scientific papers
A facile access to: N -sulfonylthioimidates and their use for the transformation to 3,4-dihydroquinazolines
Wu, Jia-Yu,Liao, Wei-Jr,Lin, Xiu-Yi,Liang, Chien-Fu
, p. 8881 - 8885 (2020/11/23)
N-Sulfonylthioimidates can be efficiently synthesized through one-pot three-component coupling of terminal alkynes, sulfonyl azides, and thiols by using a copper(i) catalyst in the presence of 4-dimethylaminopyridine. The proposed reaction is characterized by mild reaction conditions and tolerance of diverse functional groups. Additionally, the crucial pharmacophore of 3,4-dihydroquinazolines was synthesized using a one-pot synthetic strategy from N-sulfonylthioimidates. This journal is
A facile and versatile protocol for the one-pot PhI(OAc)2 mediated divergent synthesis of quinazolines from 2-aminobenzylamine
Saha, Moumita,Mukherjee, Prasun,Das, Asish R.
supporting information, p. 2044 - 2049 (2017/05/04)
In this present work iodobenzenediacetate (PIDA) has been found to be the key reagent in absence or presence of catalytic amount of molecular iodine (I2)/zinc chloride (ZnCl2) to construct quinazoline scaffold from 2-aminobenzylamine and a variety of easily available aldehydes, aryl and aliphatic amines, aliphatic and aryl alcohols and nitriles. This protocol provides mild and robust conditions along with great versatility to synthesize 2-substituted quinazolines from diverse starting materials in good to excellent yields. The developed protocol is also well applicable to reactants containing ease to oxidation prone functional groups.
Synthesis of 2-substituted quinazolines by CsOH-mediated direct aerobic oxidative cyclocondensation of 2-aminoarylmethanols with nitriles in air
Yao, Song,Zhou, Kaijing,Wang, Jiabing,Cao, Hongen,Yu, Lei,Wu, Jianzhang,Qiu, Peihong,Xu, Qing
supporting information, p. 2945 - 2951 (2017/07/24)
By using air as the superior oxidant, a highly atom-efficient synthesis of 2-substituted quinazolines is developed by a CsOH-mediated direct aerobic oxidative reaction of the readily available and stable 2-aminoarylmethanols and nitriles. Effectively working as the promoter in the alcohol oxidation, nitrile hydration, and cyclocondensation steps, CsOH is the best base for the reaction. A similar method can also be extended to the synthesis of substituted quinolines starting from methyl ketones instead of nitriles.
Synthesis of 2-substituted quinazolines via iridium catalysis
Fang, Jie,Zhou, Jianguang,Fang, Zhijie
, p. 334 - 336 (2013/03/28)
An iridium-catalyzed hydrogen transfer reaction was successfully applied in the synthesis of 2-substituted quinazolines in moderate yields starting from aldehydes or alcohols with 2-aminobenzylamines.
STUDIES ON 4-QUINAZOLINONES. PART IX. RANEY NICKEL DESULPHURISATION OF 4-THIOQUINAZOLINES: ALUMINA CATALYSED HYDRATION OF 1,4- AND 3,4-DIHYDROQUINAZOLINES
Chakrabarty, Manas,Chakravarty, Ajit K.,Pakrashi, Satyesh C.
, p. 445 - 450 (2007/10/02)
A number of 2-substituted 3,4-dihydroquinazolines and 1,2-disubstituted 1,4-dihydroquinazolines but not the 3-mono or 2,3-disubstituted derivatives, prepared by Raney nickel desulphurisation of the corresponding 4-thioquinazolines (IV), underwent unusual
