622862-42-4Relevant academic research and scientific papers
Synthesis and characterisation of novel tricyclic and tetracyclic furoindoles: Biological evaluation as SAHA enhancer against neuroblastoma and breast cancer cells
Bingul, Murat,Arndt, Greg M.,Marshall, Glenn M.,Black, David Stc.,Cheung, Belamy B.,Kumar, Naresh
, (2021/09/28)
The dihydropyranoindole structures were previously identified as promising scaffolds for improving the anti-cancer activity of histone deacetylase inhibitors. This work describes the synthesis of related furoindoles and their ability to synergize with suberoylanilide hydroxamic acid (SAHA) against neuroblastoma and breast cancer cells. The nucleophilic substitution of hydroxyin-dole methyl esters with α-haloketones yielded the corresponding arylether ketones, which were subsequently cyclized to tricyclic and tetracyclic furoindoles. The furoindoles showed promising individual cytotoxic efficiency against breast cancer cells, as well as decent SAHA enhancement against cancer cells in select cases. Interestingly, the best IC50 value was obtained with the non-cyclized intermediate.
Iron(II) triflate as a catalyst for the synthesis of indoles by intramolecular C-H amination
Bonnamour, Julien,Bolm, Carsten
supporting information; experimental part, p. 2012 - 2014 (2011/06/28)
A practical iron-catalyzed intramolecular C-H amination reaction and its application in the synthesis of indole derivatives are presented. As a catalyst, commercially available iron(II) triflate is used.
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases
Smaill, Jeff B.,Lee, Ho H.,Palmer, Brian D.,Thompson, Andrew M.,Squire, Christopher J.,Baker, Edward N.,Booth, R. John,Kraker, Alan,Hook, Ken,Denny, William A.
, p. 929 - 933 (2008/09/20)
Pyrrolo[3,4-c]carbazoles bearing solubilising basic side chains at the 8-position retain potent Wee1 and Chk1 inhibitory properties in isolated enzyme assays, and evidence of G2/M checkpoint abrogation in several cellular assays. Co-crystal structure stud
