622862-91-3Relevant academic research and scientific papers
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases
Smaill, Jeff B.,Lee, Ho H.,Palmer, Brian D.,Thompson, Andrew M.,Squire, Christopher J.,Baker, Edward N.,Booth, R. John,Kraker, Alan,Hook, Ken,Denny, William A.
, p. 929 - 933 (2008/09/20)
Pyrrolo[3,4-c]carbazoles bearing solubilising basic side chains at the 8-position retain potent Wee1 and Chk1 inhibitory properties in isolated enzyme assays, and evidence of G2/M checkpoint abrogation in several cellular assays. Co-crystal structure stud
