62291-95-6Relevant academic research and scientific papers
1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES
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Page/Page column 226, (2016/07/05)
The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
Amphiphilic amide nitrones: A new class of protective agents acting as modifiers of mitochondrial metabolism
Durand, Grégory,Poeggeler, Burkhard,Ortial, Stéphanie,Polidori, Ange,Villamena, Frederick A.,B?ker, Jutta,Hardeland, Rüdiger,Pappolla, Miguel A.,Pucci, Bernard
scheme or table, p. 4849 - 4861 (2010/10/19)
Our group has demonstrated that the amphiphilic character of α-phenyl-N-tert-butyl nitrone based agents is a key feature in determining their bioactivity and protection against oxidative toxicity. In this work, we report the synthesis of a new class of am
NOVEL AMPHIPHILIC DERIVATIVES OF ALPHA-C-PHENYL-N-TERT-BUTYLNITRONE
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Page/Page column 6-7; sheet 1, (2009/12/24)
Compounds derived from α-C-phenyl-N-tert-butylnitrone, a process for the preparation thereof and use thereof for the preparation of medicaments for use in preventing or treating oxidative stress-related diseases.
Novel ampiphilic derivatives of alpha-c-phenyl-n-tert-butyl nitrone
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Page/Page column 10, (2008/06/13)
Novel compounds, derivatives of α-C-phenylN-tert-butyl nitrone, a method for production and use thereof for the preparation of medicaments for the prevention or treatment of diseases related to oxidative stress.
Synthesis of a new family of glycolipidic nitrones as potential antioxidant drugs for neurodegenerative disorders
Durand, Gregory,Polidori, Ange,Salles, Jean-Pierre,Pucci, Bernard
, p. 859 - 862 (2007/10/03)
This paper deals with the synthesis of a novel series of amphiphilic glycosylated spin-traps derived from α-Phenyl-N-tert-butyl nitrone (PBN) and an initial characterization of their anti-caspase-3 activity. Preliminary investigation of their anti-apoptos
