76-39-1

Usage

Purification Methods

Distil it under vacuum and/or crystallise it from pet ether or MeOH. [Astle & Abbott J Org Chem 21 1229 1956, Kambe & Yasuda Bull Soc Chem Jpn 41 1444 1968, Beilstein 1 H 378, 1 III 1546, 1 IV 1604.]

InChI:InChI=1/C4H9NO3/c1-4(2,3-6)5(7)8/h6H,3H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 79-46-9 2-nitropropane 
• 74-89-5 methylamine 
• 7732-18-5 water 
• 5447-97-2 2-bromo-2-nitropropane 
• 71481-64-6 formaldehyde(methanol 44%, water 10%) 
• 77-49-6 2-Methyl-2-nitro-1,3-propanediol 
• 597-09-1 2-nitro-2-ethyl-1,3-propanediol 
• 126-11-4 2-hydroxymethyl-2-nitro-propane-1,3-diol 

Downstream Products

• 17697-46-0 1,1-Dimethyl-1-nitro-2-piperidinoethan 
• 33453-98-4 4-(2-methyl-2-nitropropyl)morpholine 
• 204707-41-5 benzyl-(β-nitro-isobutyl)-ether 
• 6263-70-3 Bis-(2-methyl-2-nitro-propyl)-formal 
• 63765-90-2 (2-ethyl-hexyl)-(β-nitro-isobutyl)-amine 
• 854235-33-9 benzyl-biphenyl-4-yl-(β-nitro-isobutyl)-amine 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 811-93-8 1,1-dimethylethylenediamine 
• 73825-68-0 cyclohexyl-(β-nitro-isobutyl)-amine 
• 95173-63-0 N-(β-nitro-isobutyl)-p-toluidine 

Relevant academic research and scientific papers

Preparation method of 2-nitro-2-methyl-1-propanol crystal

The invention provides a preparation method of a 2-nitro-2-methyl-1-propanol crystal. According to the method, 2-nitro-2-methyl-1-propanol is prepared through a reaction between 2-nitropropane and paraformaldehyde, the residual formaldehyde is removed with an acidic solid catalyst, and the product is subjected to secondary purification with cyclohexane so as to obtain the 2-nitro-2-methyl-1-propanol crystal, wherein the purity is up to 99.8-99.99%, and the residual formaldehyde is 5-200 ppm; and the conversion rate of the reaction based on 2-nitropropane can be 98-99.7%, and the final yield after the secondary purification is 90-97%.

Green synthesis method for one-pot process preparation of AMP-95

The invention discloses a green synthesis method for the one-pot process preparation of AMP-95. The method comprises the following steps: S1, preparing 2-nitropropane from acetone, hydrogen peroxide and ammonia in an alcohol solution under the catalysis of a catalyst; S2, directly reacting a reaction solution obtained in step S1 with formaldehyde or paraformaldehyde under an alkaline condition without purifying in order to generate 2-nitro-2-methyl-1-propanol; and S3, directly hydrogenating the reaction product obtained in step S2 without purifying to obtain the product 2-amino-2-methy-1-propanol (AMP-95), and rectifying the product to make the purity reach 99.5% or more. The method has the advantages of cheap and easily available raw materials, simple reaction steps, small pollution to the environment, low cost, high yield, easiness in purification of the product, and suitableness for industrial production.

A 2-nitro-2-methyl-1-propanol

The invention relates to a method for preparing 2-nitro-2-methyl-1-propanol. The method comprises the following steps: (1) dissolving an alkali in an alcohol solvent to obtain a solution and dissolving paraformaldehyde in the solution to obtain a dissolving solution, wherein the mass ratio of alcohol to alkali to paraformaldehyde is equal to 1: (0.005-0.05): (0.2-2); (2) adding the dissolving solution into 2-nitropropane for reacting, after the reaction is completed, neutralizing with an acid and then filtering to obtain a filtrate, wherein the molar ratio of 2-nitropropane to paraformaldehyde in the step (1) is equal to 1: (0.5-2); and (3) distilling the filtrate under reduced pressure to obtain 2-nitro-2-methyl-1-propanol crystals. The method is simple in process and is easily operated, and the yield of the product is high. Since alcohol is used as a solvent, the energy consumption during the concentration is reduced and the industrial continuous production is easily achieved.

Synthesis and Evaluation of a Library of Trifunctional Scaffold-Derived Compounds as Modulators of the Insulin Receptor

We designed a combinatorial library of trifunctional scaffold-derived compounds, which were derivatized with 30 different in-house-made azides. The compounds were proposed to mimic insulin receptor (IR)-binding epitopes in the insulin molecule and bind to and activate this receptor. This work has enabled us to test our synthetic and biological methodology and to prove its robustness and reliability for the solid-phase synthesis and testing of combinatorial libraries of the trifunctional scaffold-derived compounds. Our effort resulted in the discovery of two compounds, which were able to weakly induce the autophosphorylation of IR and weakly bind to this receptor at a 0.1 mM concentration. Despite these modest biological results, which well document the well-known difficulty in modulating protein-protein interactions, this study represents a unique example of targeting the IR with a set of nonpeptide compounds that were specifically designed and synthesized for this purpose. We believe that this work can open new perspectives for the development of next-generation insulin mimetics based on the scaffold structure.

DEGRADABLE POLYURETHANES AND COMPOSITES THEREOF

Among others, the present invention provides isocyanate resin compositions which include an isocyanate compound containing two or more isocyanate functional groups; a chain extender comprising a degradable diamine and optionally a dihydric alcohol, a polyether diol, a polyester diol, a diamine, a dimercaptan, or a bisphenol; and a cross-linker comprising a degradable polyamine and optionally a trifunctional, tetrafunctional or polyfunctional polyhydric alcohol, polyether polyol, polyester polyol, polyamine, polymercaptan, or polyphenol.

PROCESS FOR THE PREPARATION OF NITROALCOHOLS

A process of preparing a nitroalcohol, e.g., 2-nitro-2-methyl-1-propane, from a nitropolyol, e.g., 2-nitro-2 -methyl-1,3-propanediol, the process comprising the step of contacting under hydrogenation conditions the nitropolyol with hydrogen, a hydrogenation catalyst and, optionally, a chelating agent.

PROCESS FOR MAKING TERTIARY AMINOALCOHOL COMPOUNDS

A process for making a tertiary aminoalcohol compound is disclosed. The process comprises using an excess amount of a carbonyl compound in a condensation step between the carbonyl compound and a nitroalkane in the presence of a catalytic amount of a tertiary aminoalcohol compound, and conducting a hydrogenation/alkylation step to produce the tertiary aminoalcohol. The tertiary aminoalcohol compound used to catalyze the condensation step is preferably the same tertiary aminoalcohol compound produced in the hydrogenation/alkylation step. The process uses fewer steps than conventional processes.

PROCESS FOR MAKING TERTIARY AMINOALCOHOL COMPOUNDS

Provided is a process for making a tertiary aminoalcohol compound. The process comprises using an excess amount of a carbonyl compound in a condensation step between the carbonyl compound and a nitroalkane, and conducting a hydrogenation/alkylation step to produce the tertiary aminoalcohol. The process uses fewer steps than conventional processes.

Convenient procedure for the indium-mediated hydroxymethylation of active bromo compounds: Transformation of ketones into α-hydroxymethyl nitroalkanes

A very simple, safe and powerful method for the hydroxymethylation of 2-bromoesters and lactones under anhydrous conditions that avoids the use of gaseous formaldehyde is described. Moreover, under these conditions, bromonitroalkanes were converted into the corresponding α- monohydroxymethylated nitroalkanes, which are precursors of the corresponding α-amino acids. Considering the easy transformation of ketones into bromonitroalkanes, this represents a method for the formal synthesis of α-amino acids from ketones. Georg Thieme Verlag Stuttgart New York.