623-85-8

Usage

Synthesis Reference(s)

Synthetic Communications, 11, p. 475, 1981 DOI: 10.1080/00397918108061879

InChI:InChI=1/C6H13NO2/c1-3-5-7-6(8)9-4-2/h3-5H2,1-2H3,(H,7,8)

Upstream product

• 2414-98-4 magnesium ethylate 
• 98-88-4 benzoyl chloride 
• 500109-16-0 (bis-propylcarbamoyl-methyl)-carbamic acid tert-butyl ester 
• 107-10-8 propylamine 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 19935-86-5 N-nitroso-N-n-propylurethane 
• 67566-32-9 (3-oxo-2,3-diphenyl-propionyl)-propyl-carbamic acid ethyl ester 

Relevant academic research and scientific papers

Concise route to α-acylamino-β-keto amides: Application to the synthesis of a simplified azinomycin A analogue

Condensation of acid chlorides (alkyl, aryl or heteroaryl) with N,N′-dialkyl α-acylamino malonamides in the presence of magnesium ethoxide provides a direct route to α-acylamino-β-keto amides in moderate to good yields (46-95%). Using this method, a conci

REACTIONS OF DIETHYL CARBONATE WITH AMINES CATALYZED BY METAL CENTRES

In the presence of several metal compounds as catalysts such as AlCl3, SnCl2, ZnCl2, Zn(O2CCH3)2*2H2O, FeCl3, "RuCl3*3H2O", RhCl3*3H2O, Rh(PPh3)3Cl, and Ru(PPh3)3Cl2, the reaction of diethyl carbonate, (C2H5O)2CO, with 1-propylamine at 60 deg C and under a dinitrogen atmosphere gives the corresponding carbamate, CH3(CH2)2NHCO2C2H5.The catalytic activity increases by increasing the acidic nature of the metal centre.Compounds such as FeCl3 and AlCl3 were found inactive when the reaction was carried out with aniline instead of 1-propylamine.Preliminary results have shown that FeCl3 is also active as catalyst in the reaction of CH3CO2C2H5 with 1-propylamine to give the corresponding amide CH3CONH(CH2)2CH3.